Table 1.

OR of breast cancer among 2,569 cases and 2,588 controls, and corresponding 95% CI according to daily intake of flavonoids (Italy, 1991-1994)

FlavonoidsMedian*Quintile of intake
χ2 TrendOR, continuous
12345
Flavanones
    Upper cutpoint (mg)33.711.529.137.762.2
    OR (95% CI)1.001.19 (1.00-1.43)1.11 (0.92-1.33)1.15 (0.96-1.38)0.95 (0.79-1.15)0.48 (0.49)0.95 (0.87-1.04)
Flavan-3-ols
    Upper cutpoint (mg)36.418.130.344.179.7
    OR (95% CI)1.000.98 (0.82-1.18)0.80 (0.66-0.98)1.01 (0.83-1.23)0.86 (0.71-1.05)1.28 (0.26)0.93 (0.87-0.99)
Flavonols
    Upper cutpoint (mg)18.612.616.421.529.9
    OR (95% CI)1.000.81 (0.67-0.98)1.00 (0.83-1.21)0.82 (0.67-1.00)0.80 (0.66-0.98)3.52 (0.06)0.94 (0.88-1.01)
Flavones
    Upper cutpoint (mg)0.50.20.30.50.6
    OR (95% CI)1.000.94 (0.79-1.13)0.97 (0.81-1.17)0.86 (0.71-1.04)0.81 (0.66-0.98)5.41 (0.02)0.90 (0.83-0.97)
Anthocyanidins
    Upper cutpoint (mg)10.43.77.914.320.5
    OR (95% CI)1.001.03 (0.86-1.25)1.16 (0.95-1.40)1.11 (0.90-1.37)1.09 (0.87-1.36)0.76 (0.38)1.06 (0.96-1.17)
Isoflavones (μg)
    Upper cutpoint21.713.419.025.234.7
    OR (95% CI)1.001.05 (0.87-1.27)1.00 (0.83-1.22)1.02 (0.84-1.24)1.05 (0.86-1.29)0.08 (0.78)0.97 (0.91-1.04)
  • * Median intake among controls.

  • Estimates from multiple logistic regression models including terms for age, study center, education, parity, alcohol consumption, and nonalcohol energy intake.

  • OR for a difference in intake equal to the difference between the upper cutpoints of the fourth and that of the first quintile.