Table 4.

ORs (95% CI s) for the association of quartiles of selected total antioxidant intake with ovarian cancer, Hawaii and Los Angeles, 1993-1999

Q2 vs Q1Q3 vs Q1Q4 vs Q1P for trend*
All women
    Vitamin C (mg)0.98 (0.69-1.38)0.75 (0.52-1.08)0.89 (0.62-1.26)0.65
    Vitamin E (total α-E mg)1.12 (0.78-1.60)0.93 (0.64-1.37)0.80 (0.56-1.16)0.10
    Selenium (mg)1.18 (0.81-1.71)1.22 (0.80-1.87)0.98 (0.58-1.66)0.66
Premenopausal women (n = 217 cases and 256 controls)
    Vitamin C (mg)0.97 (0.56-1.69)0.52 (0.29-0.91)0.89 (0.50-1.59)0.83
    Vitamin E (total α-E mg)1.00 (0.57-1.76)0.93 (0.50-1.71)0.83 (0.42-1.66)0.57
    Selenium (mg)1.12 (0.56-2.23)1.18 (0.56-2.49)1.05 (0.42-2.62)0.94
Postmenopausal women (n = 341 cases and 351 controls)
    Vitamin C (mg)1.05 (0.66-1.66)0.99 (0.60-1.62)0.91 (0.57-1.46)0.55
    Vitamin E (total α-E mg)1.31 (0.81-2.21)1.01 (0.61-1.67)0.99 (0.50-1.24)0.06
    Selenium (mg)1.26 (0.80-1.98)1.34 (0.78-2.32)0.59 (0.36-0.97)0.05
Mucinous tumors (n = 109 cases and 607 controls)
    Vitamin C (mg)0.67 (0.38-1.19)0.41 (0.22-0.76)0.50 (0.26-0.95)0.09
    Vitamin E (total α-E mg)0.94 (0.53-1.67)0.53 (0.27-1.06)0.39 (0.19-0.81)0.02
    Selenium (mg)1.86 (0.93-3.71)1.77 (0.79-3.93)0.78 (0.27-2.21)0.18
Nonmucinous tumors (n = 449 cases and 607 controls)
    Vitamin C (mg)1.11 (0.76-1.61)0.90 (0.61-1.32)1.03 (0.71-1.51)0.95
    Vitamin E (total α-E mg)1.18 (0.80-1.73)1.08 (0.72-1.61)0.94 (0.64-1.39)0.34
    Selenium (mg)1.06 (0.72-1.57)1.12 (0.72-1.76)1.03 (0.60-1.80)0.98
Smokers (n = 207 cases and 240 controls)
    Vitamin C (mg)1.23 (0.69-2.21)0.45 (0.24-0.84)0.69 (0.40-1.19)0.17
    Vitamin E (total α-E mg)1.32 (0.72-2.45)0.60 (0.31-1.15)0.75 (0.40-1.38)0.34
    Selenium (mg)1.38 (0.70-2.51)1.12 (0.55-2.26)0.69 (0.29-1.68)0.17
Nonsmokers (n = 351 cases and 367 controls)
    Vitamin C (mg)0.87 (0.56-1.35)0.90 (0.57-1.43)1.00 (0.62-1.61)0.72
    Vitamin E (total α-E mg)1.15 (0.61-2.17)0.78 (0.39-1.56)0.73 (0.38-1.41)0.23
    Selenium (mg)1.11 (0.70-1.76)1.27 (0.74-2.20)1.19 (0.61-2.32)0.67
Drinkers (n = 203 cases and 238 controls)
    Vitamin C (mg)0.89 (0.49-1.60)0.54 (0.29-1.02)0.69 (0.39-1.24)0.34
    Vitamin E (total α-E mg)1.09 (0.59-2.01)0.84 (0.45-1.56)1.07 (0.56-2.05)0.86
    Selenium (mg)0.98 (0.51-1.86)1.05 (0.50-2.21)0.72 (0.30-1.72)0.33
Nondrinkers (n = 354 cases and 369 controls)
    Vitamin C (mg)0.98 (0.64-1.52)0.84 (0.54-1.32)0.99 (0.62-1.57)0.93
    Vitamin E (total α-E mg)1.01 (0.65-1.59)0.97 (0.61-1.55)0.80 (0.51-1.27)0.26
    Selenium (mg)1.34 (0.84-2.13)1.33 (0.78-2.27)1.18 (0.60-2.35)0.87
  • NOTE: ORs after adjustment for age, ethnicity, study site, education, oral contraceptive pill use, pregnancy status, tubal ligation, and energy intake by polytomous logistic regression (histologic type) or unconditional logistic regression (all other variables). Quartile/tertile cut points for antioxidants were as follows: vitamin C, 149.1, 252.4, and 555.3 mg; vitamin E, 10.5, 19.9, and 52.1 mg; selenium, 81.4, 109.9, and 146.3 mg. Total antioxidant intake includes both food and supplement sources.

  • * Based on the likelihood ratio test comparing models with and without a trend variable that was assigned the median for the categories.