Table 4.

The effect of smoking and NSAID use on DNA damage levels in Barrett's esophagus and control patients

Mean % tail DNA (95% CI)
Barrett's esophagus group
Control group
Squamous (no Fapy glycosylase)Barrett's (no Fapy glycosylase)Gastric (no Fapy glycosylase)Squamous (no Fapy glycosylase)Squamous (Fapy glycosylase)
Smoke
    Never13.7 (11.8-15.9, n = 25)*21.8 (20.2-23.4)*18.3 (15.9-21.1)16.8 (14.9-18.8, n = 32)23.0 (20.5-25.8)
    Ever16.8 (14.5-19.4, n = 25)24.9 (22.2-28.0)22.0 (18.8-25.8)19.2 (16.4-22.4, n = 32)28.6 (25.4-32.2)
Adjusted for age, sex and NSAID/aspirin
    Never20.7 (14.4-30.0)*21.5 (16.6-28.2)21.1 (14.3-31.5)13.7 (10.6-18.0)19.5 (15.6-24.5)*
    Ever26.8 (17.8-40.0)24.8 (18.5-33.1)25.8 (16.8-40.0)15.6 (11.8-20.7)23.6 (18.4-30.3)
NSAID/aspirin
    No15.0 (13.3-16.9, n = 42)23.2 (21.5-25.1)19.8 (17.5-22.3)18.6 (16.6-20.7, n = 53)26.8 (24.3-29.5)*
    Yes15.8 (12.1-20.6, n = 8)23.6 (19.6-28.5)21.7 (17.2-27.4)15.1 (13.0-17.6, n = 11)21.3 (18.0-25.1)
Adjusted for age, sex, smoking, and PPI use
    No21.3 (16.8-26.8)24.5 (20.9-29.1)22.6 (17.6-29.4)18.5 (14.9-23.1)29.1 (23.8-35.5)§
    Yes27.1 (18.0-40.4)25.3 (19.1-33.8)26.3 (16.9-40.9)15.3 (11.4-20.5)23.8 (18.2-30.9)
  • * P < 0.05 (t test for means between never and ever smoking or current use or not of NSAID/aspirin).

  • P < 0.01 (t test for means between never and ever smoking or current use or not of NSAID/aspirin).

  • P = 0.058 (t test for means between never and ever smoking).

  • § P = 0.056 (t test for means between current use or not of NSAID/aspirin).