Table 3.

Reflux risk factors and their effect on DNA damage levels in the comet assay (without Fapy glycosylase) in Barrett's esophagus and control patients

Reflux risk factorMean % tail DNA (95% CI)
Barrett's esophagus group
Controls
SquamousBarrett'sGastricSquamous
Current reflux symptoms
    No15.3 (13.6-17.1, n = 35)23.0 (21.2-24.9)19.6 (17.4-22.0)16.5 (14.6-18.7*, n = 43)
    Yes14.8 (11.5-19.1, n = 15)24.0 (20.6-28.0)21.3 (16.8-27.0)21.2 (18.5-24.3, n = 21)
Previous reflux symptoms
    NoNANANA16.4 (14.1-19.2, n = 22)
    Yes15.1 (13.6-16.8, n = 50)23.3 (21.7-25.0)20.1 (18.1-22.3)18.8 (16.6-21.2, n = 42)
Nocturnal reflux
    No14.9 (12.2-18.2, n = 13)23.6 (20.6-27.1)21.0 (17.8-24.7)17.0 (15.2-18.9, n = 42)
    Yes15.2 (13.4-17.3, n = 37)23.2 (21.3-25.2)19.8 (17.3-22.6)20.0 (16.5-24.1, n = 22)
Hiatus hernia
    No14.2 (12.2-16.5, n = 28)22.5 (20.3-25.0)20.4 (17.4-24.0)17.9 (16.3-19.5, n = 59)
    Yes16.5 (14.2-19.0, n = 22)24.3 (22.2-26.7)19.7 (17.1-22.6)18.8 (7.2-49.2, n = 5)
  • NOTE: Not applicable (NA) as all Barrett's esophagus patients reported reflux symptoms.

  • * P = 0.013 (t test for means between no/ yes groups).