DNA damage as a risk factor for development of esophageal adenocarcinoma (adenocarcinoma or high-grade dysplasia)
| DNA damage (% tail) in Barrett's tissue (no Fapy glycosylase) | No. Barrett's esophagus patients | No. esophageal adenocarcinoma patients | Odds ratio, crude (95% CI) | P crude | Adjusted odds ratio (95% CI) | P adjusted | |
|---|---|---|---|---|---|---|---|
| 1st quartile | <20.7 | 16 | 3 | 1.0 (reference) | 1.0 (reference) | ||
| 2nd quartile | 20.7-23.6 | 11 | 7 | 3.4 (0.7-16.1) | 0.124 | 7.2 (0.9-60.1) | 0.068 |
| 3rd quartile | 23.6-28.1 | 14 | 5 | 1.9 (0.4-9.4) | 0.430 | 2.0 (0.2-17.9) | 0.538 |
| 4th quartile | >28.1 | 9 | 9 | 5.3 (1.1-24.9) | 0.033 | 9.4 (1.1-83.4) | 0.044 |
NOTE: Data adjusted for age, sex, nocturnal reflux, smoking, and PPI medication.