Patient details
| Controls | No SIM | Barrett's esophagus | Esophageal adenocarcinoma | |
|---|---|---|---|---|
| No. | 64 | 9 | 50 | 24 |
| Mean age (range) | 52 (28-83) | 53 (32-69) | 63 (30-82) | 70 (58-86) |
| Sex (M/F) | 36:28* | 7:2 | 34:16 | 20:4 |
| Current reflux symptoms | 21 (33) | 2 (22) | 15 (30) | 5 (21) |
| Previous reflux symptoms | 42 (66)‡ | 8 (89) | 50 (100) | 21 (88) |
| Nocturnal reflux (%) | 22 (34)‡ | 5 (56) | 37 (74) | 9 (38) |
| Duration of reflux (median years, range) | 3 (1-26)† | 5.5 (4-20) | 10 (1-50) | 10 (1-50) |
| Hiatus hernia | 5 (8)‡ | 1 (11) | 22 (44) | NI |
| Esophagitis | 9 (14) | 1 (11) | 6 (12) | NI |
| Ever smoking | 32 (50) | 2 (22) | 25 (50) | 13 (54) |
| Alcohol | 48 (75) | 7 (78) | 38 (76) | 16 (67) |
| NSAID/aspirin | 11 (17) | 1 (11) | 8 (16) | 6 (25) |
| Current PPI use | 26 (41) | 9 (100) | 42 (84) | 16 (67) |