Table 1.

Participant characteristics of HNSCC cases and controls

CharacteristicsCases, n (%)Controls, n (%)All HNSCC, OR (95% CI)*Oral cavity only, OR (95% CI)Pharynx only, OR (95% CI)Larynx only, OR (95% CI)§
Age (y)
    <52143 (27.4)141 (23.5)
    >52-60133 (25.5)153 (25.5)
    >60-68123 (23.6)151 (25.2)
    >68122 (23.4)154 (25.7)
Gender
    Male375 (72.0)430 (71.8)
    Female146 (28.0)169 (28.2)
Race
Caucasian446 (85.6)540 (90.2)
    Black23 (4.4)21 (3.5)
    Other50 (9.6)37 (6.2)
    Missing2 (0.4)1 (0.2)
Tobacco (pack-years)
    0100 (19.2)198 (33.1)1.01.01.01.0
    >0-1577 (14.8)129 (21.5)1.2 (0.8-1.7)1.0 (0.6-1.5)1.5 (0.8-2.6)1.9 (0.8-4.3)
    >15-3592 (17.7)118 (19.7)1.7 (1.2-2.5)1.8 (1.2-2.8)1.5 (0.8-2.7)2.5 (1.1-5.6)
    >35-58107 (20.5)94 (15.7)2.6 (1.8-3.7)2.0 (1.3-3.3)2.7 (1.5-4.9)5.6 (2.6-12)
    >58145 (27.8)60 (10.0)5.6 (3.8-8.4)4.0 (2.5-6.6)5.6 (3.1-10)14.8 (6.9-32)
Tobacco (pack-years)
    None100 (19.2)198 (33.1)1.01.01.01.0
    Light169 (32.4)247 (41.2)1.4 (1.0-1.9)1.3 (0.9-2.0)1.5 (0.9-2.5)2.1 (1.0-4.4)
    Heavy252 (48.4)154 (25.7)3.7 (2.6-5.1)2.7 (1.8-4.1)3.9 (2.3-6.5)8.9 (4.4-18)
Alcohol (drinks/wk)
    081 (15.5)108 (18.0)1.01.01.01.0
    >0-690 (17.3)190 (31.7)0.7 (0.5-1.0)0.6 (0.4-1.0)0.7 (0.4-1.3)0.9 (0.5-1.0)
    >6-1174 (14.2)113 (18.9)1.0 (0.7-1.5)1.0 (0.6-1.7)1.0 (0.5-2.1)1.2 (0.7-1.5)
    >11-26119 (22.8)117 (19.5)1.7 (1.1-2.5)1.5 (0.9-2.5)1.9 (1.0-3.5)2.2 (1.1-2.5)
    >26156 (29.9)69 (11.5)3.7 (2.4-5.7)4.0 (2.3-6.7)4.5 (2.4-8.4)2.9 (2.4-5.7)
Missing1 (0.2)2 (0.3)
Alcohol (drinks/wk)
    None81 (15.5)108 (18.0)1.01.01.01.0
    Light298 (57.2)433 (72.3)1.0 (0.7-1.4)0.9 (0.6-1.4)1.1 (0.6-1.8)1.4 (0.7-2.6)
    Heavy141 (27.1)56 (9.3)3.8 (2.5-6.0)4.2 (2.5-7.2)4.9 (2.6-9.3)2.6 (1.2-5.8)
    Missing1 (0.2)2 (0.3)
ADH1C
    1*1197 (37.8)240 (40.1)1.01.01.01.0
    1*2242 (46.4)273 (45.6)1.1 (0.9-1.4)1.2 (0.9-1.7)0.8 (0.6-1.2)1.3 (0.8-2.1)
    2*282 (15.7)86 (14.4)1.2 (0.9-1.8)1.1 (0.7-1.7)1.0 (0.6-1.8)1.9 (1.0-3.5)
Total521599
  • * All HNSCC (521 cases), adjusted for age, gender, and race.

  • Oral cavity (256 cases, includes ICD-9 codes 140, 141 143, 144, and 145), adjusted for age, gender, and race.

  • Pharynx (149 cases, includes ICD-9 codes 146, 148, and 149), adjusted for age, gender, and race.

  • § Larynx (106 cases, includes ICD-9 code 161), adjusted for age, gender, and race.

  • Cutpoint for heavy tobacco is 35 pack-years.

  • Cutpoint for heavy alcohol is 30 per week.