Table 3.

RR and 95% CI for measures of recreational physical activity at various points in time and pancreatic cancer, CPS-II Nutrition Cohort, 1992-1999

MET-hours per week (1992)
None>0-7>7-17.5>17.5-31.5>31.5Ptrend*
Men
    No. cases/person-years12/51,17944/130,05642/126,30232/97,2777/30,801
    Age-standardized rate27.9737.3336.3533.9524.11
    RR (95% CI)1 (reference)1.39 (0.73-2.63)1.33 (0.70-2.53)1.29 (0.66-2.51)0.91 (0.36-2.30)
    RR§ (95% CI)1 (reference)1.45 (0.76-2.75)1.43 (0.74-2.73)1.41 (0.72-2.77)1.01 (0.39-2.60)0.84 (0.52 among active)
Women
    No. cases/person-years12/42,85241/163,52823/154,90320/88,9879/28,466
    Age-standardized rate35.1028.2215.3322.5535.49
    RR (95% CI)1 (reference)0.89 (0.47-1.69)0.52 (0.26-1.05)0.78 (0.38-1.59)1.13 (0.48-2.69)
    RR§ (95% CI)1 (reference)1 (0.52-1.91)0.62 (0.30-1.25)0.92 (0.44-1.89)1.42 (0.59-3.41)0.73 (0.65 among active)
    Men + women
    RR§,
1 (reference)
1.24 (0.79-1.96)
1 (0.62-1.61)
1.17 (0.72-1.91)
1.20 (0.63-2.27)
0.97 (0.82 among active)

MET-hours per week (age 40)
None
>0-7
>7-17.5
>17.5-31.5
>31.5
Ptrend*
Men
    No. cases/person-years22/72,19637/109,54929/99,75636/94,27812/54,225
    Age-standardized rate36.7936.2431.0639.4225.81
    RR (95% CI)1 (reference)1.09 (0.64-1.85)0.94 (0.54-1.64)1.18 (0.69-2)0.70 (0.35-1.42)
    RR (95% CI)§1 (reference)1.09 (0.64-1.85)0.95 (0.54-1.65)1.19 (0.70-2.02)0.69 (0.34-1.41)0.40 (0.32 among active)
Women
    No. cases/person-years16/68,68537/138,62523/130,08616/83,85111/49,870
    Age-standardized rate25.1729.9220.5319.9623.88
    RR (95% CI)1 (reference)1.12 (0.62-2.02)0.76 (0.40-1.43)0.78 (0.39-1.55)0.94 (0.44-2.02)
    RR§ (95% CI)1 (reference)1.15 (0.64-2.07)0.77 (0.41-1.46)0.77 (0.38-1.53)0.94 (0.44-2.03)0.38 (0.41 among active)
    Men + women
    RR§, (95% CI)
1 (reference)
1.15 (0.78-1.70)
0.88 (0.58-1.34)
1.03 (0.67-1.56)
0.81 (0.48-1.36)
0.24 (0.19 among active)

Exercise (1982)**
None/slight
Moderate
Heavy
Ptrend*


Men
    No. cases/person-years45/112,96073/268,27619/51,413
    Age-standardized rate48.7128.8636.57
    RR (95% CI)1 (reference)0.62 (0.43-0.90)0.89 (0.52-1.52)
    RR§ (95% CI)1 (reference)0.70 (0.48-1.02)1.12 (0.64-1.95)0.69 (0.75 among active)
Women
    No. cases/person-years30/128,52467/319,6256/24,935
    Age-standardized rate27.5322.5524.77
    RR (95% CI)1 (reference)0.79 (0.51-1.22)0.91 (0.38-2.18)
    RR§ (95% CI)1 (reference)0.84 (0.54-1.29)0.97 (0.40-2.35)0.59 (0.43 among active)
    Men + women
    RR§, (95% CI)1 (reference)0.74 (0.56-0.99)1.04 (0.65-1.65)0.38 (0.34 among active)
  • * Trend tests conducted in multivariate models.

  • Age-standardized incidence rates per 100,000 standardized to the sex-specific distribution of Nutrition Cohort participants.

  • Age-adjusted RR and corresponding 95% CI.

  • § Multivariate-adjusted hazard RR and 95% CI adjusted for: age, smoking status, years since quitting smoking among former smokers, education, family history of pancreatic cancer, personal history of gallbladder disease, personal history of diabetes, height, total caloric intake, and MET-hours per week in 1992.

  • Also adjusted for gender.

  • One case in men (5,610 person-years) and two cases in women (7,618 person-years) not included due to missing information on physical activity at age 40.

  • ** No cases in men (2,966 person-years) and two cases in women (5,652 person-years) not included due to missing 1982 exercise information.