Table 2.

RR and 95% CI for measure of obesity at various times during a participant's lifetime and pancreatic cancer, CPS-II Nutrition Cohort, 1992-1999

BMI [weight (kg)/height (m)2] at baseline (1992)
<2525 to <3030+Ptrend*
Men
    No. cases/person-years44/155,03157/218,53636/62,047
    Age-standardized rate29.012967.71
    RR (95% CI)1 (reference)1.00 (0.67-1.48)2.43 (1.55-3.80)
    RR§ (95% CI)1 (reference)0.99 (0.66-1.47)2.38 (1.50-3.78)0.0004
Women
    No. cases/person-years50/250,57033/154,59422/73,572
    Age-standardized rate21.8422.9135.19
    RR (95% CI)1 (reference)1.07 (0.69-1.66)1.66 (1.00-2.74)
    RR§ (95% CI)1 (reference)1.09 (0.70-1.70)1.73 (1.02-2.92)0.06
    Men + women
    RR§, (95% CI)
1 (reference)
1.03 (0.76-1.38)
2.08 (1.48-2.93)
0.0001



BMI (weight (kg)/height (m2) at age 18
<21
21 to <23
23+
Ptrend*


Men
    No. cases/person-years48/175,97832/117,07356/136,460
    Age-standardized rate28.4128.9549.53
    RR (95% CI)1 (reference)1.07 (0.68-1.67)1.70 (1.15-2.50)
    RR§,**1 (reference)1.06 (0.67-1.67)1.43 (0.94-2.19)0.09
Women
    No. cases/person-years59/294,89625/107,36317/71,824
    Age-standardized rate21.8725.1327.95
    RR (95% CI)1 (reference)1.18 (0.74-1.88)1.25 (0.73-2.15)
    RR§,** (95% CI)1 (reference)1.15 (0.71-1.85)1.06 (0.59-1.89)0.77
    Men + women
    RR§,,** (95% CI)
1 (reference)
1.07 (0.77-1.49)
1.33 (0.95-1.85)
0.11



Adult weight change (age 18 to 1992), kg
>−2.27
−2.27 to +4.54
+4.55 to +9.07
+9.08 to +13.61
+13.62 or more
Ptrend*
Men
    No. cases/person-years11/15,89112/61,24221/71,90115/76,01477/204,464
    Age-standardized rate75.4820.9731.5522.9840.64
    RR (95% CI)3.67 (1.62-8.32)1 (reference)1.50 (0.74-3.04)1.02 (0.48-2.17)1.99 (1.08-3.65)
    RR§,** (95% CI)3.54 (1.56-8.03)1 (reference)1.49 (0.73-3.04)0.97 (0.45-2.11)1.59 (0.82-3.08)0.36
Women
    No. cases/person-years4/21,16820/86,92018/86,51321/83,55138/195,931
    Age-standardized rate19.8025.1121.9328.4221.70
    RR (95% CI)0.79 (0.27-2.32)1 (reference)0.93 (0.49-1.75)1.12 (0.61-2.08)0.87 (0.50-1.49)
    RR§, (95% CI)0.71 (0.24-2.08)1 (reference)0.89 (0.47-1.68)0.95 (0.50-1.80)0.50 (0.25-1)0.22
    Men + women
    RR,,∥,** (95% CI)
1.74 (0.94-3.22)
1 (reference)
1.12 (0.70-1.79)
0.97 (0.60-1.58)
0.96 (0.61-1.52)
0.16

Location of weight gain††
Peripheral weight gain
Central weight gain




Men
    No. cases/person-years18/71,964103/275,518
    Age-standardized rate25.8841.21
    RR (95% CI)1 (reference)1.53 (0.92-2.52)
    RR§,** (95% CI)1 (reference)1.51 (0.92-2.50)
Women
    No. cases/person-years38/193,58724/86,474
    Age-standardized rate24.1727.76
    RR (95% CI)1 (reference)1.21 (0.73-2.02)
    RR§,** (95% CI)1 (reference)1.36 (0.80-2.30)
    Men + women
    RR§,,** (95% CI)1 (reference)1.45 (1.02-2.07)
  • * Trend tests conducted in multivariate models.

  • Age-standardized incidence rates per 100,000 standardized to the sex-specific distribution of Nutrition Cohort participants.

  • Age-adjusted RR and corresponding 95% CI.

  • § Multivariate-adjusted hazard RR and 95% CI adjusted for: age, smoking status, years since quitting smoking among former smokers, education, family history of pancreatic cancer, personal history of gallbladder disease, personal history of diabetes, height, total caloric intake, and MET-hours per week in 1992.

  • Also adjusted for gender.

  • One case in men (6,103 person-years) and four cases in women (4,653 person-years) not included due to missing BMI at age 18.

  • ** Also adjusted for BMI in 1992.

  • †† Sixteen cases in men (88,132 person-years) and 43 cases in women (198,675 person-years) not included due to report of inconsistent or other locations of weight gain. Central weight gain defined as weight gain in “waist” or “chest and shoulders” and peripheral weight gain defined as “hips and thighs” or “equally all over.”