Table 6.

ORs and 95% CIs for endometrial cancer risk in relation to the number of putative low-risk CYP1A1, CYP1A2, and CYP1B1 genotypes carried

No. putative low-risk genotypes carriedCases (n = 371)
Controls (n = 420)
OR, age adjusted (95% CI)Putative low-risk genotypes*
nFrequencynFrequencyCYP1A1 m1 ≥1 CCYP1A1 m2 ≥1 ValCYP1A1 m4 Thr/ThrCYP1A2 AACYP1B1 Leu/Leu
090.02450.012
11020.2751110.264X
1150.040150.036X
130.00830.007X
0 and any 11290.3471340.3191.00 (Reference)
240.011100.024XX
210.00320.004XX
2890.240930.221XX
2440.119540.129XX
240.01190.021XX
Any 21420.3841680.3990.89 (0.64-1.24)
3110.03060.014XXX
30010.002XXX
3220.059190.045XXX
310.00340.010XXX
320.00500XXX
3510.137410.098XXX
Any 3870.234710.1691.27 (0.85-1.89)
430.008130.031XXXX
40060.014XXXX
40010.002XXXX
470.019200.048XXXX
530.00870.017XXXXX
Any 4 and 5130.035470.1120.29 (0.15-0.56)
  • NOTE: For example, in the first row, with a “0” in column 1, 9 (2.4%) cases and 5 (1.2%) controls carried a genotype combination that included no low-risk genotypes at CYP1A1 m1, m2, and m4; CYP1A2; and CYP1B1 (designated by a “—” in each of those columns). In the second to last row, with a “5” in column 1, 3 (0.8%) cases and 7 (1.7%) controls carried a low-risk genotype at all loci (designated by a “X” in each of the columns). In the last row, with “Any 4 and 5” in column 1, the numbers and frequencies in bold are the sums of all the rows containing genotypes with four and five putative low-risk genotypes.

  • * “X” in the column indicates the presence of the genotype. Only genotype combinations that were present in the cases or controls are shown.