Table 4.

Univariate linear regression analysis of molecular biomarkers against risk factors, adjusted for age

VariablesnTotal nuclear area (%)
Epithelial nuclear area (%)
Nonepithelial nuclear area (%)
Collagen (%)
Glandular area (%)
Estimates (SE)P*Estimates (SE)P*Estimates (SE)P*Estimates (SE)P*Estimates (SE)P*
Age (y)236−0.02 (0.003)<0.0001−0.01 (0.002)<0.0001−0.006 (0.001)<0.0001−0.23 (0.08)0.004−0.03 (0.006)<0.0001
Height (m)2360.77 (0.89)0.390.66 (0.61)0.280.11 (0.33)0.73−1.81 (20.20)0.930.98 (1.63)0.55
Weight (kg)236−0.01 (0.004)0.01−0.01 (0.003)0.03−0.01 (0.001)0.01−0.46 (0.10)<0.0001−0.01 (0.01)0.08
Body mass index (kg/m2)236−0.04 (0.01)0.002−0.02 (0.01)0.01−0.01 (0.004)0.001−1.023 (0.26)<0.0001−0.04 (0.02)0.04
Age at first menstruation (y)72−0.11 (0.08)0.18−0.05 (0.05)0.34−0.06 (0.03)0.051.66 (1.54)0.28−0.05 (0.13)0.71
Age at first birth (y)82−0.02 (0.03)0.4−0.01 (0.02)0.56−0.01 (0.01)0.180.24 (0.53)0.65−0.06 (0.03)0.10
No. birth139−0.02 (0.03)0.50−0.02 (0.02)0.36−0.002 (0.01)0.85−2.34 (0.82)0.005−0.05 (0.06)0.33
Age at menstruation stop (y)360.01 (0.01)0.430.01 (0.01)0.16−0.001 (0.01)0.920.44 (0.67)0.52−0.01 (0.02)0.50
Ethnicity
    Hispanic2360.15 (0.17)0.240.10 (0.12)0.110.05 (0.06)0.693.18 (3.90)0.020.21 (0.32)0.61
    Anglo0.28 (0.17)0.23 (0.12)0.05 (0.06)9.68 (3.78)0.31 (0.31)
Menopausal status232−0.68§ (0.20)0.001−0.45§ (0.14)0.001−0.23§ (0.07)0.002−10.20§ (4.58)0.03−1.55§ (0.36)<0.0001
Parous status164−0.15 (0.18)0.40−0.08 (0.12)0.49−0.06 (0.06)0.31−9.03 (3.82)0.02−0.33 (0.27)0.23
Ever taken birth control pills1010.26 (0.21)0.210.16 (0.14)0.260.11 (0.08)0.17−2.83 (5.07)0.580.34 (0.34)0.32
Ever taken hormone replacement therapy99−0.27 (0.25)0.28−0.19 (0.16)0.24−0.07 (0.09)0.430.48 (5.77)0.94−0.60 (0.38)0.12
Family history of breast cancer970.50** (0.42)0.240.031** (0.28)0.280.19** (.15)0.207.29** (0.26)0.480.68** (0.71)0.34
Breast size
    Small2350.82†† (0.19)<0.00010.51†† (0.13)0.0010.31†† (0.07)<0.000111.22†† (4.36)0.011.10†† (0.35)0.01
    Medium0.29†† (0.16)0.19†† (0.11)0.10†† (0.06)0.49†† (3.62)0.69††(0.29)
  • * Univariate linear regression analysis of the corresponding molecular biomarkers listed in the top row against the corresponding variables in the left column and adjusted for age (i.e., biomarker = the corresponding variable listed in the left column + age).

  • Variables with missing data.

  • Native American serves as the reference group.

  • § Postmenopausal versus premenopausal.

  • Parous versus nulliparous.

  • Ever versus never.

  • ** With versus without family history.

  • †† Large size serves as the reference group.