Table 3.

Linear regression analysis of mammograpbic density against each of the breast tissue measurement

AgeNMean (SD)Estimates (SE)P*R2 (baseline R2 = 0.02)
All
    Total nuclear areas (%)2360.97 (0.99)7.40 (1.71)<0.0010.09
    Epithelial nuclear area (%)2360.49 (0.67)9.11 (2.53)<0.0010.07
    Nonepithelial nuclear area (%)2360.48 (0.36)23.51 (4.61)<0.0010.12
    Collagen (%)23628.02 (21.58)0.63 (0.07)<0.0010.29
    Glandular area (%)2361.79 (1.78)2.34 (0.96)<0.0010.04
<50 y
    Total nuclear areas (%)1601.15 (1.11)6.76 (1.72)<0.00010.14
    Epithelial nuclear area (%)1600.62 (0.76)8.63 (2.53)<0.00080.12
    Nonepithelial nuclear area (%)1600.53 (0.39)21.24 (4.81)<0.00010.16
    Collagen (%)16030.32 (21.10)0.60 (0.08)<0.00010.30
    Glandular area (%)1602.14 (1.97)2.46 (0.99)<0.01390.09
≥50 y
    Total nuclear areas (%)760.58 (0.48)11.33 (6.36)0.07900.06
    Epithelial nuclear area (%)760.22 (0.29)10.18 (10.69)0.34410.03
    Nonepithelial nuclear area (%)760.36 (0.23)32.73 (12.91)0.01340.10
    Collagen (%)7623.16 (21.92)0.66 (0.11)<0.00010.32
    Glandular area (%)761.07 (0.96)−0.23 (3.16)0.94330.02
  • * Univariate linear regression analysis of mammographic density against the corresponding biomarkers, adjusted for age.

  • R2 for the linear regression model.