Table 4.

Results of meta-analysis examining breast cancer risk associated with CYP1B1 and COMT gene polymorphisms

StudyPopulationNo. of subjects
OR (95% CI)*References
CaseControl
CYP1B1 codon 119 (reference: Ala/Ala)Ala/SerSer/Ser
    Watanabe et al.Japanese3393611.62 (1.15-2.29)0.60 (0.11-3.31)(27)
    Rylander-Rudqvist et al.Swedish1,4991,3381.00 (0.90-1.20)1.00 (0.80-1.30)(9)
    Dunning et al.Caucasian, United Kingdom9978120.99 (0.81-1.20)1.12 (0.78-1.60)(28)
    Overall2,8352,5111.12 (0.88-1.41)1.04 (0.84-1.28)(9, 27, 28)
    This studyChinese1,1341,2121.00 (0.83-1.19)0.75 (0.48-1.17)
    Overall3,9693,7231.07 (0.91-1.25)0.98 (0.81-1.19)
        Test for heterogeneityP = 0.065P = 0.560
CYP1B1 codon 432 (reference: Leu/Leu)Leu/ValVal/Val
    Bailey et al.Caucasian Americans, African Americans2232230.81 (0.52-1.28)1.09 (0.63-1.89)(10)
    Watanabe et al.Japanese3363240.90 (0.63-1.27)1.10 (0.36-3.31)(27)
    De Vivo et al.Caucasian Americans4534531.46 (1.08-1.96)1.27 (0.88-1.84)(11)
    Kocabas et al.Turkish841032.68 (1.43-5.02)1.27 (0.47-3.43)(8)
    Rylander-Rudqvist et al.Swedish1,4841,3361.00 (0.90-1.20)1.00 (0.80-1.30)(9)
    Lee et al.Korean2412901.00 (0.70-1.60)1.10 (0.30-4.70)(12)
    Dunning et al.Caucasian, United Kingdom1,6178450.78 (0.62-0.98)0.85 (0.67-1.08)(28)
    Thyagarajan et al.Caucasian Americans, African Americans1643381.16 (0.66-2.06)1.27 (0.78-2.07)(29)
    Overall4,6023,9121.09 (0.88-1.34)1.01 (0.88-1.16)(8–12, 27–29)
    This studyChinese1,1101,1951.00 (0.82-1.22)0.86 (0.49-1.52)
    Overall5,7125,1071.06 (0.90-1.26)1.01 (0.88-1.15)
        Test for heterogeneityP = 0.005P = 0.832
CYP1B1 codon 453 (reference: Asn/Asn)Asn/SerSer/Ser
    Bailey et al.Caucasian Americans, African Americans2232230.96 (0.62-1.49)1.24 (0.33-4.71)(10)
    De Vivo et al.Caucasian Americans4534530.88 (0.64-1.20)0.57 (0.23-1.42)(11)
    Rylander-Rudqvist et al.Swedish1,4891,3340.90 (0.80-1.10)0.90 (0.60-1.50)(9)
    Overall2,1652,0100.91 (0.79-1.04)0.85 (0.54-1.34)(9–11)
        Test for heterogeneityP = 0.920P = 0.306
COMT (reference: Val/Val)Val/MetMet/Met
    Lavigne et al.Caucasian Americans1131141.34 (0.67-2.69)1.42 (0.69-2.94)(30)
    Millikan et al.Caucasian Americans, African Americans6546420.80 (0.62-1.02)0.80 (0.59-1.09)(14)
    Thompson et al.Caucasian Americans2812891.30 (0.90-1.90)0.80 (0.50-1.40)(31)
    Huang et al.Chinese1181250.65 (0.37-1.16)3.15 (0.89-12.1)(32)
    Mitrunen et al.Finnish4814800.84 (0.59-1.20)0.75 (0.51-1.11)(15)
    Yim et al.Korean1631632.30 (1.35-3.85)0.20 (0.07-0.92)(13)
    Hamajima et al.Japanese1501651.46 (0.90-2.36)0.99 (0.49-2.02)(16)
    Bergman-Jungestrom and WingrenSwedish1261170.85 (0.35-2.10)0.87 (0.34-2.20)(17)
    Kocabas et al.Turkish841030.95 (0.50-1.81)1.35 (0.55-3.32)(8)
    Wedren et al.Swedish1,4901,3401.00 (0.80-1.20)0.90 (0.70-1.10)(18)
    Wu et al.Asian§5895620.82 (0.64-1.06)0.84 (0.54-1.30)(33)
    Comings et al.Californian671450.29 (0.15-0.57)0.30 (0.13-0.67)(34)
    Dunning et al.Caucasian, United Kingdom2,8501,9081.02 (0.88-1.18)10 (0.93-1.29)(28)
    Overall7,1666,1530.97 (0.81-1.15)0.89 (0.74-1.07)(8, 13–18, 28, 30–34)
    This studyChinese1,1201,1910.93 (0.78-1.11)0.93 (0.68-1.27)
    Overall8,2867,3440.96 (0.83-1.12)0.89 (0.76-1.05)
        Test for heterogeneityP < 0.001P = 0.023
    Caucasian women (from refs. 14, 15, 17, 18, 28, 30, 31, 34)5,7974,7720.93 (0.77-1.12)0.88 (0.72-1.07)
        Test for heterogeneityP = 0.018P = 0.042
    Asian women (from refs. 13, 16, 32, 33, and this study)2,1402,2061.07 (0.77-1.48)0.91 (0.59-1.38)
        Test for heterogeneityP = 0.001P = 0.057
    Premenopausal women (from refs. 8, 13–17, 30–32, and this study)1,7841,8021.11 (0.82-1.50)0.97 (0.72-1.31)
        Test for heterogeneityP = 0.004P = 0.168
    Postmenopausal women (from refs. 8, 13–16, 18, 28, 30–32, and this study)5,8364,8290.98 (0.85-1.13)0.89 (0.71-1.10)
        Test for heterogeneityP = 0.124P = 0.027
  • * ORs (95% CIs) shown in italic were calculated by authors of this study.

  • Overall estimates for studies not including this study.

  • Overall estimates for studies including this study.