Table 1.

Genotype frequency of IGFBP-3−336 polymorphism in cases and controls

Cases (n = 603), n (%)Controls (n = 1,068), n (%)Odds ratio (95% CI)Odds ratio* (95% CI)
Genotype
    AA141 (23.4)243 (22.8)1.01.0
    AC298 (49.4)521 (48.8)0.98 (0.76-1.26)0.97 (0.75-1.26)
    CC164 (27.2)304 (28.5)0.93 (0.71-1.23)0.94 (0.70-1.25)
Premenopausal
    AA112 (23.5)189 (21.8)1.01.0
    AC236 (49.6)429 (49.5)0.92 (0.69-1.22)0.91 (0.68-1.22)
    CC128 (26.9)248 (28.6)0.86 (0.63-1.18)0.86 (0.62-1.19)
Postmenopausal
    AA10 (29.4)17 (26.2)1.01.0
    AC17 (50.0)29 (44.6)1.00 (0.37-2.72)0.83 (0.25-2.75)
    CC7 (20.6)19 (29.2)0.66 (0.21-2.11)0.67 (0.17-2.64)
Unknown status
    AA19 (20.4)37 (27.0)1.01.0
    AC45 (48.4)63 (46.0)1.38 (0.70-2.70)1.32 (0.64-2.69)
    CC29 (31.2)37 (27.0)1.59 (0.76-3.33)1.71 (0.77-3.75)
  • * Adjusted for family history of breast cancer, duration of breast-feeding, number of full-term pregnancies, daily amount of alcohol/gram, use of oral contraceptives, and, where appropriate, menopausal status.