Genotype frequency of IGFBP-3−336 polymorphism in cases and controls
| Cases (n = 603), n (%) | Controls (n = 1,068), n (%) | Odds ratio (95% CI) | Odds ratio* (95% CI) | |||||
|---|---|---|---|---|---|---|---|---|
| Genotype | ||||||||
| AA | 141 (23.4) | 243 (22.8) | 1.0 | 1.0 | ||||
| AC | 298 (49.4) | 521 (48.8) | 0.98 (0.76-1.26) | 0.97 (0.75-1.26) | ||||
| CC | 164 (27.2) | 304 (28.5) | 0.93 (0.71-1.23) | 0.94 (0.70-1.25) | ||||
| Premenopausal | ||||||||
| AA | 112 (23.5) | 189 (21.8) | 1.0 | 1.0 | ||||
| AC | 236 (49.6) | 429 (49.5) | 0.92 (0.69-1.22) | 0.91 (0.68-1.22) | ||||
| CC | 128 (26.9) | 248 (28.6) | 0.86 (0.63-1.18) | 0.86 (0.62-1.19) | ||||
| Postmenopausal | ||||||||
| AA | 10 (29.4) | 17 (26.2) | 1.0 | 1.0 | ||||
| AC | 17 (50.0) | 29 (44.6) | 1.00 (0.37-2.72) | 0.83 (0.25-2.75) | ||||
| CC | 7 (20.6) | 19 (29.2) | 0.66 (0.21-2.11) | 0.67 (0.17-2.64) | ||||
| Unknown status | ||||||||
| AA | 19 (20.4) | 37 (27.0) | 1.0 | 1.0 | ||||
| AC | 45 (48.4) | 63 (46.0) | 1.38 (0.70-2.70) | 1.32 (0.64-2.69) | ||||
| CC | 29 (31.2) | 37 (27.0) | 1.59 (0.76-3.33) | 1.71 (0.77-3.75) | ||||
↵* Adjusted for family history of breast cancer, duration of breast-feeding, number of full-term pregnancies, daily amount of alcohol/gram, use of oral contraceptives, and, where appropriate, menopausal status.