Table 1.

Allele frequencies (%) of the CYP1B1 and COMT genes and haplotype distribution of CYP1B1 polymorphisms, the Shanghai Breast Cancer Study

Case (n = 1,135)Control (n = 1,235)P*
Alleles
    CYP1B1
        Codon 48Arg81.3079.97
Gly18.7020.030.25
HWE0.660.85
        Codon 119Ala81.2780.53
Ser18.7319.470.52
HWE0.500.46
        Codon 432Val13.2413.43
Leu86.7686.570.85
HWE0.360.18
    COMT
Val73.6272.46
Met26.3827.540.38
HWE0.440.70
Estimated frequency of CYP1B1 haplotypes (codons 48-119-432)
    Arg-Ala-Val11.7711.400.72
    Arg-Ala-Leu68.9067.820.41
    Arg-Ser-Val0.080.000.13
    Arg-Ser-Leu0.330.380.80
    Gly-Ala-Val0.330.290.78
    Gly-Ala-Leu0.200.470.19
    Gly-Ser-Val1.041.660.19
    Gly-Ser-Leu17.1817.340.89
    Overall χ2 testP = 0.59
  • Abbreviation: HWE, Hardy-Weinberg equilibrium.

  • * P values for alleles are from χ2 test, for haplotypes from the exact test.

  • We genotyped 200 samples and found no Asn453Ser polymorphism in this study.