Table 1.

Per3 genotypes and breast cancer risk stratified by menopausal status

Genotypes*Cases, N (%)Controls, N (%)OR (95% CI)
Overall
    −/−180 (46.2)206 (47.7)1.0
    +/−173 (44.5)198 (45.8)1.1 (0.8-1.4)
    +/+36 (9.3)28 ( 6.5)1.5 (0.9-2.5)
    +/− and +/+209 (53.8)226 (52.3)1.1 (0.8-1.5)
Premenopausal Women
    −/−33 (37.5)76 (51.0)1.0
    +/−47 (53.4)64 (43.0)1.7 (1.0-3.0)
    +/+8 (9.1)9 ( 6.0)1.8 (0.6-5.3)
    +/− and +/+55 (62.5)73 (49.0)1.7 (1.0-3.0)
Postmenopausal Women
    −/−147 (48.8)130 (45.9)1.0
    +/−126 (41.9)134 (47.4)0.9 (0.6-1.2)
    +/+28 (9.3)19 (6.7)1.4 (0.7-2.6)
    +/− and +/+154 (51.2)153 (54.1)0.9 (0.7-1.3)
  • * −/− Homozygous 4-repeat allele; +/− heterozygous alleles; +/+ homozygous 5-repeat allele.

  • Adjusted for age, family history of breast cancer, family income, body mass, age at menarche, age at first birth, and county.