Table 2.

Breast cancer incidence by frequency of current NSAID use, CPS-II Nutrition Cohort, 1992-2001

NSAID pills per monthCases/person-yearsMultivariate-adjusted rate ratios (95% CI)*
Total NSAIDs
    None1,207/234,7831.00 (reference)
    1-14684/113,5751.11 (1.01-1.22)
    15-29283/52,5571.02 (0.89-1.16)
    30-59444/80,6881.02 (0.91-1.14)
    ≥60340/67,4411.07 (0.96-1.21)
Aspirin
    None1,759/328,7031.00 (reference)
    1-14625/98,0301.14 (1.04-1.25)
    15-29180/38,2090.89 (0.76-1.03)
    30-59314/59,3280.96 (0.85-1.09)
    ≥60130/24,7751.01 (0.84-1.20)
Ibuprofen
    None2,262/418,1051.00 (reference)
    1-14388/68,1841.04 (0.93-1.16)
    15-29116/20,9541.04 (0.86-1.25)
    30-59106/18,6401.04 (0.86-1.26)
    ≥60136/23,1621.06 (0.89-1.26)
Other NSAIDs
    None2,692/498,1231.00 (reference)
    1-1484/14,8880.95 (0.76-1.18)
    15-2922/5,3290.71 (0.46-1.07)
    30-5995/13,6931.20 (0.98-1.48)
    ≥60115/17,0121.16 (0.96-1.40)
  • NOTE: Current NSAID use is defined as use reported on the last completed questionnaire (as reported in 1992 for follow-up through 1997, as reported in 1997 for follow-up through 1999, and as reported in 1999 for follow-up through 2001).

  • * Adjusted for age, race, education, family history of breast cancer, personal history of breast cysts, history of mammography, age at menarche, duration of oral contraceptive use, parity, age at menopause, use of hormone replacement therapy, weight change since age 18, body mass index, and alcohol consumption. Rate ratios for individual NSAID types are also adjusted for use of other types of NSAIDs.