Table 1.

Genotype frequencies of polymorphic loci in genes encoding enzymes involved in folate metabolism in breast cancer cases and controls

PolymorphismGenotype/alleleCases, n (%)Controls, n (%)ORadj (95% CI)
MTHFR_677_C>TAll*
CC249 (43)261 (41)1.00,
CT274 (47)279 (44)1.04 (0.82-1.33)
TT61 (10)93 (15)0.69 (0.48-1.00)
T(32)(37)
Premenopausal
CC62 (44)59 (40)1.00§,
CT66 (47)68 (46)0.86 (0.51-1.44)
TT13 (9)20 (14)0.60 (0.26-1.36)
Postmenopausal
CC187 (42)202 (42)1.00§,
CT208 (47)211 (43)1.06 (0.80-1.41)
TT48 (11)73 (15)0.71 (0.47-1.09)
MTHFR_1298_A>CAll*
AA273 (47)295 (47)1.00,
AC256 (44)266 (42)1.04 (0.82-1.32)
CC53 (9)73 (12)0.78 (0.53-1.16)
C(31)(32)
Premenopausal
AA65 (46)69 (47)1.00§,
AC59 (42)63 (43)1.11 (0.66-1.87)
CC16 (11)15 (10)1.22 (0.53-2.77)
Postmenopausal
AA208 (47)226 (46)1.00§,
AC197 (45)203 (42)1.04 (0.79-1.37)
CC37 (8)58 (12)0.69 (0.43-1.08)
TYMS_1494_del TAAAGTAll*
ins/ins272 (47)292 (48)1.00,
ins/del245 (43)267 (44)0.97 (0.76-1.24)
del/del58 (10)51 (8)1.22 (0.81-1.85)
del(31)(33)
Premenopausal
ins/ins55 (40)62 (45)1.00§,
ins/del67 (49)68 (49)1.08 (0.64-1.84)
del/del15 (11)9 (6)1.82 (0.69-4.79)
Postmenopausal
ins/ins217 (50)230 (49)1.00§,
ins/del178 (41)199 (42)0.94 (0.71-1.24)
del/del43 (10)42 (9)1.13 (0.70-1.81)
MTR_2756_A>GAll*
AA366 (63)415 (65)1.00,
AG197 (34)193 (30)1.17 (0.91-1.49)
GG22 (4)27 (4)0.95 (0.53-1.71)
G(21)(19)
Premenopausal
AA84 (59)89 (60)1.00§,
AG54 (38)48 (32)1.34 (0.80-2.24)
GG4 (3)11 (7)0.30 (0.09-1.09)
Postmenopausal
AA282 (64)362 (67)1.00§,
AG143 (32)145 (30)1.14 (0.86-1.52)
GG18 (4)16 (3)1.36 (0.67-2.73)
  • * Allele frequencies are in agreement with published data (13).

  • OR conditional on age in 5-year group adjusted for menopausal status, smoking status, body mass index, breast cancer in mother or sister, parity, hormone replacement therapy, and oral contraceptives.

  • Reference.

  • § OR conditional on age in 5-year group adjusted for smoking status, body mass index, breast cancer in mother or sister, parity, hormone replacement therapy, and oral contraceptives.