Table 3.

Data-dredging gene-dose analyses, permutation-corrected, with different number of loci and different sample sizes

Number of high-risk genotypesSample size (500)
Sample size (1,000)
OR*Coverage probability of the CIOR*Coverage probability of the CI
Three loci
Number of high-risk genotypes
0 to 11.00001.0000
21.00150.94871.00000.9454
31.00190.95281.00320.9519
Type I error rate of the trend test0.05100.0531
Five loci
Number of high-risk genotypes
0 to 11.00001.0000
2 to 30.99910.94591.00250.9506
4 to 51.00140.94781.00140.9532
Type I error rate of the trend test0.04940.0456
Ten loci
Number of high-risk genotypes
0 to 31.00001.0000
4 to 60.99960.94930.99970.9475
7 to 100.99820.94961.00200.9491
Type I error rate of the trend test0.04880.0498
• NOTE: The results are based on 10,000 simulations, with 1,000 permutations for each round of the simulation. Other settings are the same as those in Table 2.

• * Geometric mean of 10,000 simulations.