Number of the high-risk genotypes | Sample size (500) | Sample size (1,000) | ||||||
---|---|---|---|---|---|---|---|---|
OR* | Coverage probability of the CI | OR* | Coverage probability of the CI | |||||
Three loci | ||||||||
Number of high-risk genotypes | ||||||||
0 to 1 | 1.0000 | — | 1.0000 | — | ||||
2 | 1.1999 | 0.8906 | 1.1361 | 0.8883 | ||||
3 | 1.3924 | 0.8678 | 1.2641 | 0.8627 | ||||
Type I error rate of the trend test | 0.1605 | 0.1596 | ||||||
Five loci | ||||||||
Number of high-risk genotypes | ||||||||
0 to 1 | 1.0000 | — | 1.0000 | — | ||||
2 to 3 | 1.2820 | 0.8577 | 1.1943 | 0.8509 | ||||
4 to 5 | 1.6485 | 0.7280 | 1.4211 | 0.7300 | ||||
Type I error rate of the trend test | 0.3037 | 0.2980 | ||||||
Ten loci | ||||||||
Number of the high-risk genotypes | ||||||||
0 to 3 | 1.0000 | — | 1.0000 | — | ||||
4 to 6 | 1.4152 | 0.7399 | 1.2764 | 0.7373 | ||||
7 to 10 | 2.0005 | 0.3892 | 1.6334 | 0.3808 | ||||
Type I error rate of the trend test | 0.6348 | 0.6436 |
NOTE: The results are based on simulated case-control data (equal number of cases and controls). The loci are unlinked or in linkage equilibrium with one another. The genotypes in each loci have been classified into the “1- genotype” and the “0- genotype.” The frequencies for the 1- genotype are: 0.4, 0.5, and 0.6 (three loci); 0.3, 0.4, 0.5, 0.6, 0.7 (five loci); 0.4 (×3), 0.5 (×4), 0.6 (×3) (10 loci), and are the same in the case group and the control group. Ten thousand simulations are done for each scenario. The α level is set at 0.05.
↵* Geometric mean of 10,000 simulations.