Table 2.

Estimated haplotype frequencies for MTHFR and TYMS, adjusted OR and 95% CI by subtype of NHL

Controls (%)Total NHL
DLBCL
FL
(%)OR (CI)(%)OR (CI)(%)OR (CI)
MTHFR
677 C>T1298 A>C
    Hap ACA543 (36)415 (35)1192 (36)1143 (34)1
    Hap BCC485 (32)349 (30)0.94 (0.78-1.13)164 (30)0.96 (0.75-1.22)122 (30)0.96 (0.73-1.26)
    Hap CTA482 (32)411 (35)1.11 (0.93-1.34)184 (34)1.08 (0.85-1.37)147 (36)1.17 (0.90-1.51)
    Hap DTC0302
TYMS
1494del628–bp repeat
    Hap 16bp+2R619 (41)451 (39)1215 (40)1154 (37)1
    Hap 26bp+3R444 (30)348 (30)1.08 (0.90-1.30)141 (26)0.91 (0.71-1.17)132 (32)1.19 (0.91-1.58)
    Hap 36bp+4R0110
    Hap 46bp−2R107 (7)82 (7)1.05 (0.77-1.43)41 (8)1.09 (0.74-1.61)29 (7)1.09 (0.67-1.73)
    Hap 56bp−3R332 (22)284 (24)1.17 (0.96-1.43)134 (25)1.16 (0.90-1.49)97 (23)1.17 (0.87-1.58)
    Hap 66bp−4R221.08 (0.13-8.75)22.18 (0.26-18.01)0
  • NOTE: ORs adjusted for sex, age, and region estimated using unconditional logistic regression.