Table 2.

Significant and near significant haplotypes

Marker combinationDistance (cM)*Distance (kb)Global score PSimulated P§No. observed haplotypesStatistics for significant haplotypes Frequency
HaplotypeOverall**Cases††Controls‡‡P§§Simulated P∥∥
D3S3630-D3S10503.765600.0120.01622182-2270.03700.0850.0170.014
182-2340.0460.08500.0190.018
186-2230.01800.0580.0350.018
D11S1986-D11S134709080.0460.00345235-1770.0950.0490.1280.0330.030
227-1770.0710.1130.0220.0340.030
D22S426-D22S11771.42400.0550.02124215-1820.0500.0110.1270.0050.004
213-1860.04600.0810.0270.030
211-1800.0330.06900.0050.005
D22S1177-D22S4452.43030.0580.01828182-1150.0570.0200.1150.0090.006
188-1030.01300.0160.0340.014
180-1150.0840.1600.0140.0070.004
D2S436-D2S4107.029,4710.077NA32184-1600.153NANA0.005NA
D2S410-D2S36301,1540.095NA29169-2520.051NANA0.050NA
171-2540.036NANA0.047NA
160-2520.083NANA0.046NA
D3S3725-D3S30530600.068NA3292-2270.028NANA0.027NA
88-2230.024NANA0.040NA
  • * Genetic distance (sex average) between markers in cM (Marshfield).

  • Distance between markers in kb (Marshfield).

  • P for global test score for the difference in haplotype frequencies cases versus controls from haplo.score.

  • § Simulated P for the global score from haplo.score.

  • Number of haplotypes observed with frequency >0.5%.

  • Individual haplotypes (allele size in bp) with significant difference in allele frequencies between cases and controls.

  • ** Frequency for given haplotype in cases and controls combined.

  • †† Frequency for given haplotype in cases.

  • ‡‡ Frequency for given haplotype in controls.

  • §§ P for frequency difference of individual haplotype cases versus controls from haplo.score.

  • ∥∥ Simulated P for frequency difference of individual haplotype cases versus controls from haplo.score.