Table 3.

ORs of breast cancer (95% CI) by quartiles of IGF-I and IGFBP-3 for the subset of subjects who were part of the original study (87 cases of 136 controls)

QuartilesP trend median*Continuous (log2 scale)
1234
IGF-I
    Original method1.001.23 (0.55-2.73)2.24 (0.95-5.28)2.22 (0.94-5.25)0.031.98 (1.00-3.92)
    Number of cases and controls18/3818/3725/3126/30
    DSL ELISA method1.000.99 (0.41-2.38)2.41 (1.02-5.66)1.65 (0.69-3.99)0.091.95 (0.93-4.07)
    Number of cases and controls18/3718/3928/2823/32
IGFBP-3
    Original method1.001.92 (0.81-4.52)1.65 (0.73-3.72)2.22 (0.99-4.98)0.061.69 (0.79-3.60)
    Number of cases and controls17/4321/3022/3227/31
    DSL ELISA method1.001.45 (0.66-3.20)1.73 (0.81-3.72)2.05 (0.94-4.47)0.052.03 (0.81-5.06)
    Number of cases and controls16/4022/3423/3226/30
    Functional IGFBP-31.001.22 (0.53-2.83)0.55 (0.24-1.26)0.76 (0.28-2.06)0.240.58 (0.31-1.07)
    Number of cases and controls24/3127/3016/3920/36
IGF-I adjusted for IGFBP-3
    IGF-I, original method
        Adjusted for IGFBP-3 original method1.001.21 (0.54-2.73)2.17 (0.86-5.51)2.13 (0.79-5.73)0.101.89 (0.82-4.33)
        Adjusted for IGFBP-3 DSL ELISA1.001.21 (0.53-2.75)2.16 (0.82-5.71)2.12 (0.73-6.11)0.131.82 (0.76-4.35)
        Adjusted for functional IGFBP-31.001.34 (0.60-3.01)2.70 (1.09-6.69)2.99 (1.19-7.51)0.012.63 (1.26-5.48)
    IGF-I ELISA Method
        Adjusted for IGFBP-3 original method1.000.94 (0.38-2.29)2.19 (0.87-5.47)1.43 (0.52-3.95)0.241.77 (0.73-4.32)
        Adjusted for IGFBP-3 DSL ELISA1.000.93 (0.38-2.29)2.13 (0.83-5.51)1.37 (0.46-4.09)0.321.71 (0.64-4.52)
        Adjusted for functional IGFBP-31.001.06 (0.42-2.66)3.27 (1.29-8.30)2.37 (0.92-6.07)0.022.72 (1.22-6.08)
Molar ratios
    IGF-I original method
        IGFBP-3 original method1.002.02 (0.85-4.81)1.62 (0.65-4.06)1.86 (0.70-4.97)0.291.46 (0.69-3.10)
        IGFBP-3 DSL ELISA1.002.18 (0.88-5.43)1.56 (0.62-3.95)1.73 (0.71-4.21)0.351.67 (0.72-3.86)
        Functional IGFBP-31.001.54 (0.65-3.64)3.17 (1.27-7.92)2.34 (0.92-5.96)0.032.48 (1.39-4.42)
    IGF-I ELISA method
        IGFBP-3 original method1.001.27 (0.58-2.81)1.79 (0.78-4.10)0.83 (0.32-2.16)0.851.28 (0.59-2.78)
        IGFBP-3 ELISA1.001.39 (0.60-3.21)2.06 (0.91-4.69)1.32 (0.51-3.40)0.281.49 (0.59-3.75)
        fsFunctional IGFBP-31.001.46 (0.61-3.49)1.84 (0.71-4.74)3.72 (1.44-9.63)0.012.51 (1.36-4.62)
  • * Linear trends in ORs over the quartiles by scoring the categories according to the median (ln) hormone value for each quartile.