Table 2.

Estimated changes in salivary estradiol and progesterone concentrations (pmol/L) with 95% CI by 1 SD increase in explanatory variables

Explanatory variables*Mean ± SDOverall average estradiol (n = 206)Average midluteal estradiol (n = 192) †,Average midluteal progesterone (n = 192) ,
Measures of adiposity
    BMI, kg/m224.4 ± 3.82.2 (0.9, 3.5)2.2 (0.6, 3.8)−7.1 (−19.5, 5.4)
    Truncal fat percentage32.5 ± 7.61.7 (0.4, 3.0)1.6 (0.1, 3.2)−8.2 (−20.5, 4.1)
Fasting serum lipids
    Triglycerides, mmol/L0.86 ± 1.041.2 (−0.1, 2.5)1.4 (−0.2, 2.9)5.3 (−6.8, 17.5)
    Total cholesterol, mmol/L4.43 ± 0.790.8 (−0.6, 2.1)1.1 (−0.6, 2.7)4.0 (−8.8, 16.8)
    LDL-C, mmol/L2.52 ± 0.711.2 (−0.1, 2.6)1.6 (−0.03, 3.2)1.7 (−11.0, 14.4)
    HDL-C, mmol/L1.54 ± 0.33−1.5 (−2.8, −0.2)−1.6 (−3.2, −0.1)9.1 (−3.3, 21.5)
    Total/HDL-C ratio3.00 ± 0.812.1 (0.8, 3.4)2.3 (0.7, 3.9)−5.6 (−18.2, 7.1)
    LDL-C/HDL-C ratio1.74 ± 0.702.0 (0.7, 3.3)2.2 (0.7, 3.8)−4.2 (−16.8, 8.5)
Fasting serum hormones
    Insulin, pmol/L85 ± 591.1 (−0.2, 2.4)1.0 (−0.6, 2.5)−3.1 (−15.5, 9.2)
    IGF-I, nmol/L25.0 ± 6.3−0.6 (−2.0, 0.7)−0.3 (−1.9, 1.4)−9.7 (−22.4, 3.1)
    Leptin, pmol/L856 ± 5601.2 (−0.1, 2.5)1.3 (−0.3, 2.9)−7.1 (−19.5, 5.4)
    Testosterone, nmol/L1.5 ± 0.50.1 (−1.2, 1.4)0.8 (−0.7, 2.3)2.3 (−9.6, 14.2)
    DHEA-SO4, nmol/L4.6 ± 2.10.7 (−0.6, 2.1)1.7 (0.1, 3.3)9.3 (−3.3, 22.0)
  • NOTE: The Norwegian EBBA study. Age-adjusted linear regression analysis.

  • The conversion factor from pmol/L to pg/mL is 0.272 for estradiol and 0.314 for progesterone. The conversion factor from mmol/L to mg/dL is 88.6 for triglycerides and 38.7 for total cholesterol and HDL-C. The conversion factor from pmol/L to milliunits/L is 0.17 for insulin. The conversion factor from nmol/L to ng/dL is 765 for IGF-I. The conversion factor from pmol/L to ng/dL is 1.5 for leptin. The conversion factor from nmol/L to ng/dL is 28.8 for testosterone and 36.8 for DHEA-SO4.

  • Abbreviation: DHEA-SO4, dehydroepiandrostendione sulfate.

  • * Age at entry and measurements at day 1 to day 5 after onset of the menstrual cycle.

  • Numbers may vary due to missing serum values.

  • Includes women with aligned cycles only. Aligned cycle days +5 to +9.