Table 5.

Associations between ERβ genotypes and estrogen status and risk of colon cancer among women

ERβEstrogen status positive, OR (95% CI)Estrogen status negative, OR (95% CI)
rr1.01.4 (1.1-1.8)
Rr or RR0.5 (0.2-1.0)2.0 (1.1-3.4)
Pinteraction for estrogen status and genotype, RERI: 0.05; m: 0.02
CA repeat
    <24/<241.0 (0.6-1.9)1.7 (1.0-3.1)
    24/241.01.3 (0.7-2.5)
    ≥25/≥250.8 (0.3-2.0)6.7 (2.9-15.6)
H1.4 (0.8-2.3)1.8 (1.04-3.0)
Pinteraction for estrogen status and genotype, RERI: 0.78; m: 0.01
  • NOTE: OR values were adjusted for age, BMI, physical activity, energy intake, cigarette smoking status, dietary calcium, and dietary fiber.