Table 2.

Association between ERα and ERβ and colon and rectal cancer

Everyone
Men
Women
ERαOR (95% CI)ERαOR (95% CI)ERαOR (95% CI)
xx1.0xx1.0xx1.0
ColonXx or XX1.0 (0.9-1.1)Xx or XX1.0 (0.9-1.2)Xx or XX1.0 (0.8-1.2)
Pinteraction for genotype and gender, RERI: 0.66; m: 0.65
Rectalxx1.0xx1.0xx1.0
Xx or XX0.9 (0.8-1.1)Xx or XX1.0 (0.8-1.3)Xx or XX0.9 (0.6-1.1)
Pinteraction for genotype and gender, RERI: 0.54; m: 0.50

ERβ
OR (95% CI)
ERβ
OR (95% CI)
ERβ
OR (95% CI)
Colonrr1.0rr1.0rr1.0
RR or Rr1.1 (0.8-1.4)RR or Rr1.1 (0.8-1.6)RR or Rr1.0 (0.6-1.4)
Pinteraction for genotype and gender, RERI: 0.57; m: 0.58
Rectalrr1.0rr1.0rr1.0
RR or Rr1.2 (0.9-1.7)RR or Rr1.4 (0.9-2.1)RR or Rr1.0 (0.6-1.7)
Pinteraction for genotype and gender, RERI: 0.36; m: 0.39

CA repeats
OR (95% CI)
CA repeats
OR (95% CI)
CA repeats
OR (95% CI)
Colon<24/<241.2 (0.9-1.5)<24/<241.1 (0.8-1.5)<24/<241.2 (0.9-1.8)
24/241.024/241.024/241.0
≥25/≥251.4 (0.9-2.0)≥25/≥251.0 (0.6-1.6)≥25/≥252.1 (1.2-3.6)
H1.1 (0.9-1.4)H0.9 (0.6-1.2)H1.4 (1.0-2.0)
Pinteraction for genotype and gender, RERI: <0.01; m: 0.03
Rectal<24/<240.9 (0.6-1.3)<24/<240.7 (0.4-1.2)<24/<241.1 (0.7-2.0)
24/241.024/241.024/241.0
≥25/≥250.9 (0.5-1.6)≥25/≥250.8 (0.4-1.8)≥25/≥251.1 (0.5-2.4)
H0.9 (0.6-1.2)H0.8 (0.5-1.3)H0.9 (0.6-1.5)
Pinteraction for genotype and gender, RERI: 0.69; m: 0.43
  • NOTE: Data were adjusted for age, sex, and race.

    Abbreviations: m, multiplicative interaction; H, heterozygote defined as any combination of <24, 24, or >25 CA repeats.