Table 1.

Description of study population

Colon
Rectal
Cases, n (%)Controls, n (%)Cases, n (%)Controls, n (%)
Site
    KPMCP763 (48.2)814 (41.2)506 (63.5)627 (61.7)
    Utah247 (15.6)363 (18.4)291 (36.5)389 (38.3)
    Minnesota573 (36.2)799 (40.4)NANA
Age (y)
    <4023 (1.5)40 (2.0)20 (2.5)22 (2.2)
    40-49102 (6.5)126 (6.4)100 (12.6)110 (10.8)
    50-59297 (18.8)330 (16.8)209 (26.2)256 (25.2)
    60-69549 (34.8)682 (34.7)270 (33.9)349 (34.4)
    70-79609 (38.5)790 (40.1)198 (24.8)279 (27.5)
Ethnicity
    White Caucasian1,446 (91.7)1,835 (93.3)653 (83.0)861 (85.7)
    Hispanic61 (3.9)78 (4.0)54 (6.9)71 (7.1)
    African American70 (4.4)53 (2.7)30 (3.8)40 (4.0)
    Asian0040 (5.1)31 (3.1)
    AIAN0010 (1.3)2 (0.2)
Sex
    Male887 (56.1)1,051 (53.4)469 (58.9)572 (56.3)
    Female693 (43.9)917 (46.6)328 (41.1)444 (43.7)
ERα
    xx632 (42.8)774 (42.6)334 (43.3)407 (41.4)
    Xx679 (45.9)812 (44.7)342 (44.3)455 (46.2)
    XX167 (11.3)230 (12.7)96 (12.4)122 (12.4)
ERβ
    rr1,449 (93.1)1,802 (93.4)704 (89.9)909 (91.6)
    Rr103 (6.6)125 (6.5)75 (9.6)77 (7.8)
    RR4 (0.3)2 (0.1)4 (0.5)6 (0.6)
ERβ* (CA repeats)
    9-19268 (8.8)339 (8.9)154 (10.5)166 (8.8)
    20299 (9.8)423 (11.1)160 (10.9)233 (12.4)
    21101 (3.3)110 (2.9)48 (3.3)73 (3.9)
    22198 (6.5)227 (5.9)94 (6.4)116 (6.2)
    23497 (16.2)597 (15.6)238 (16.2)320 (17.0)
    241,017 (33.2)1,357 (35.5)487 (33.1)601 (32.0)
    25494 (16.1)543 (14.2)200 (13.6)276 (14.7)
    26-34190 (6.2)225 (5.9)89 (6.1)93 (5.0)
AR* (CAG repeats)
    9-1661 (2.7)77 (2.7)30 (2.7)21 (1.5)
    1733 (1.5)41 (1.5)19 (1.7)26 (1.8)
    18130 (5.8)184 (6.5)62 (5.6)76 (5.3)
    19228 (10.2)292 (10.3)121 (11.0)152 (10.6)
    20251 (11.3)372 (13.1)104 (9.5)147 (10.2)
    21408 (18.3)467 (16.5)179 (16.3)259 (18.0)
    22255 (11.4)310 (11.0)121 (11.0)159 (11.1)
    23228 (10.2)316 (11.2)148 (13.5)148 (10.3)
    24235 (10.5)280 (9.9)119 (10.8)182 (12.7)
    25165 (7.4)211 (7.5)89 (8.1)118 (8.2)
    26103 (4.6)137 (4.8)49 (4.5)64 (4.5)
    2756 (2.5)49 (1.7)22 (2.0)37 (2.6)
    2841 (1.8)54 (1.9)17 (1.6)19 (1.3)
    29-4137 (1.7)42 (1.5)19 (1.7)23 (2.0)
  • Abbreviations: AIAN, American Indian and Alaska native; NA, not applicable.

  • * Reports numbers of alleles, rather than individuals, with the CA and CAG repeat; therefore, numbers are greater than the population studied.