Table 3.

Adjusted risk of endometrial cancer in association with regular aspirin and acetaminophen use, by BMI—Roswell Park Cancer Institute (1982-1998)

All endometrial cancers, OR* (95% CI) [cases/controls]Ideal (BMI, 18.5-24.9 kg/m2), OR (95% CI) [cases/controls]Overweight (BMI, 25-30 kg/m2), OR (95% CI) [cases/controls]Obese (BMI, >30 kg/m2), OR (95% CI) [cases/controls]
Regular aspirin user§
    No249 (58)/252 (59)65 (52)/138 (59)72 (62)/71 (67)100 (60)/34 (45)
    Yes178 (42)/175 (41)60 (48)/96 (41)45 (38)/35 (33)70 (41)/41 (55)
    Adjusted OR (95% CI)0.91 (0.66-1.26)1.61 (0.71-1.90)1.21 (0.65-2.23)0.50 (0.27-0.92)
Regular acetaminophen user§
    No§361 (85)/378 (89)107 (86)/211 (90)96 (82)/96 (91)146 (86)/63 (84)
    Yes66 (15)/49 (11)18 (14)/23 (10)21 (18)/10 (9)24 (14)/12 (16)
    Adjusted OR (95% CI)0.96 (0.60-1.54)1.49 (0.83-2.12)2.00 (0.76-4.52)0.89 (0.40-1.82)
  • * Adjusted for age, education, BMI, parity, age at menarche, age at menopause and parity.

  • Cases/controls classified as regular user; n (%).

  • Adjusted for age, education and age at menopause.

  • § Defined as use of at least one tablet a week for at least 6 months.