Table 5.

Association between sports/recreational physical activity and hormones stratified by menopausal status (mean ±SE) among a sample of 667 women with breast cancer

Tertile 1 (<2.6 MET-h/wk; n = 236)Tertile 2 (2.6-13.2 MET-h/wk; n = 238)Tertile 3 (>13.3 MET-h/wk; n = 236)P for trend
C-peptide (ng/mL)
    Premenopausal2.02 ± 0.131.91 ± 0.101.86 ± 0.090.33
    Postmenopausal2.40 ± 0.072.46 ± 0.072.27 ± 0.080.27
Leptin (ng/mL)
    Premenopausal18.4 ± 1.821.6 ± 1.417.5 ± 1.30.68
    Postmenopausal27.3 ± 0.924.8 ± 0.925.0 ± 1.00.099
IGF-I (ng/mL)
    Premenopausal153.6 ± 9.3160.7 ± 7.5171.0 ± 6.80.14
    Postmenopausal123.6 ± 3.8126.9 ± 3.8126.8 ± 4.00.56
IGFBP-3 (μg/mL)
    Premenopausal3.89 ± 0.144.17 ± 0.124.26 ± 0.10*0.046
    Postmenopausal4.05 ± 0.074.05 ± 0.074.08 ± 0.080.77
IGF-I:IGFBP-3
    Premenopausal39.4 ± 2.039.3 ± 1.640.2 ± 1.40.73
    Postmenopausal30.4 ± 0.831.5 ± 0.831.0 ± 0.80.60
  • NOTE: Sample sizes for premenopausal women: tertile 1 (n = 31), tertile 2 (n = 45), and tertile 3 (n = 58). Sample sizes for postmenopausal women: tertile 1 (n = 189), tertile 2 (n = 176), and tertile 3 (n = 168). Adjusted for study site, age, ethnicity, education, disease stage, adjuvant treatment, tamoxifen use, type 2 diabetes, smoking status, and BMI.

  • * P < 0.05, tertile 3 significantly different from tertile 1.