Table 3.

Association between sports/recreational physical activity and hormones/peptides (mean ±SE) among a sample of 710 women with breast cancer

Tertile 1 (<2.6 MET-h/wk; n = 236)Tertile 2 (2.6-13.2 MET-h/wk; n = 238)Tertile 3 (>13.3 MET-h/wk; n = 236)P for trend
C-peptide (ng/mL)
    Unadjusted2.49 ± 0.072.34 ± 0.072.04 ± 0.07*,0.001
    Adjusted2.48 ± 0.072.35 ± 0.072.04 ± 0.07*,0.001
    Adjusted§2.33 ± 0.062.35 ± 0.062.19 ± 0.060.13
Leptin (ng/mL)
    Unadjusted30.5 ± 1.124.5 ± 1.118.9 ± 1.1*,0.001
    Adjusted30.0 ± 1.124.5 ± 1.119.4 ± 1.1*,0.001
    Adjusted§26.1 ± 0.824.3 ± 0.823.4 ± 0.8*0.020
IGF-I (ng/mL)
    Unadjusted119.7 ± 3.7136.1 ± 3.7144.7 ± 3.7*0.0001
    Adjusted125.8 ± 3.4134.9 ± 3.3140.0 ± 3.4*0.0037
    Adjusted§129.5 ± 3.4135.0 ± 3.3136.2 ± 3.4*0.018
IGFBP-3 (μg/mL)
    Unadjusted3.96 ± 0.064.09 ± 0.064.18 ± 0.06*0.011
    Adjusted3.99 ± 0.064.08 ± 0.064.16 ± 0.06*0.055
    Adjusted§4.02 ± 0.064.08 ± 0.064.14 ± 0.060.17
IGF-I:IGFBP-3
    Unadjusted30.2 ± 0.833.5 ± 0.834.5 ± 0.8*0.0001
    Adjusted31.3 ± 0.733.3 ± 0.733.6 ± 0.7*0.024
    Adjusted§32.1 ± 0.433.3 ± 0.732.8 ± 0.70.47
  • * P < 0.05, tertile 3 significantly different from tertile 1.

  • P < 0.05, tertile 3 significantly different from tertile 2.

  • Adjusted for study site, age, ethnicity, education, menopausal status, disease stage, adjuvant treatment, tamoxifen use, type 2 diabetes, and smoking status.

  • § Adjusted for all the above covariates, including BMI.

  • P < 0.05, tertile 2 significantly different from tertile 1.