Table 3.

Risks of advanced colorectal adenoma associated with EPHX1 genotypes in the PLCO Cancer Screening Trial

Case (%), n = 772*Control (%), n = 777*Minor allele frequency in controlsOR (95% CI)
EPHX1 113Tyr allele
    0 (low)56 (7.9)80 (11.0)0.311.0
    1 (medium)299 (42.0)291 (39.9)1.5 (1.0-2.2)
    2 (high)357 (50.1)358 (49.1)1.5 (1.0-2.2)
Ptrend0.2
EPHX1 139Arg allele
    0 (low)443 (63.1)479 (66.2)0.191.0
    1 (medium)228 (32.5)221 (30.5)1.1 (0.9-1.4)
    2 (high)31 (4.4)24 (3.3)1.4 (0.8-2.5)
Ptrend0.2
Combined number of 113Tyr or 139Arg alleles
    0-1 (low)245 (31.7)263 (33.9)1.0
    2 (medium)285 (36.9)317 (40.8)1.0 (0.8-1.8)
    3-4 (high)242 (31.4)197 (25.4)1.4 (1.0-1.8)
Ptrend0.03
  • * Numbers do not add up to the total because of missing values.

  • Adjusted for gender, race, and age.