Table 4.

Association between genotypes and anthrophometric measures and hormones of the growth hormone/IGF-I axis

VariableGH1 −57G>T Genotype, mean (SE)
F (P)GH1 −75G>A Genotype, mean (SE)
F (P)
GG (n = 138)GT (n = 153)TT (n = 57)GG/GA (n = 68)AA (n = 280)
All women
Height* (cm)163.18 (0.68)162.31 (0.61)161.73 (0.90)1.17 (0.31)161.58 (0.89)162.65 (0.50)1.41 (0.24)
Weight (kg)69.45 (1.63)65.77 (1.48)64.94 (2.18)2.44 (0.09)65.49 (2.17)67.11 (1.21)0.35 (0.56)
BMI* (kg/m2)25.92 (0.61)24.61 (0.55)24.47 (0.81)2.07 (0.13)24.59 (0.81)25.10 (0.45)0.22 (0.64)
Waist/hip ratio0.76 (0.01)0.77 (0.01)0.77 (0.01)1.14 (0.32)0.76 (0.01)0.76 (0.004)0.00 (0.99)
Waist (cm)73.11 (0.58)73.83 (0.53)74.10 (0.77)0.69 (0.50)72.93 (0.76)73.77 (0.43)0.77 (0.38)
All women
Growth hormone (μg/L)1.48 (0.28)1.74 (0.26)1.86 (0.37)0.68 (0.51)1.32 (0.37)1.74 (0.21)5.42 (0.02)
IGF-I (μg/L)140.46 (3.46)141.10 (3.11)146.72 (4.59)0.51 (0.60)139.35 (4.53)142.45 (2.54)0.56 (0.45)
IGFBP-3 (mg/L)2.68 (0.05)2.77 (0.05)2.82 (0.07)2.03 (0.13)2.68 (0.07)2.76 (0.04)1.29 (0.26)
IGF-I/IGFBP-30.20 (0.004)0.19 (0.004)0.20 (0.005)0.87 (0.42)0.19 (0.005)0.19 (0.003)0.00 (0.98)
Prolactin (μg/L)13.30 (0.99)12.94 (0.89)14.22 (1.31)0.37 (0.69)13.50 (1.29)13.27 (0.73)0.09 (0.76)
  • * Adjusted for age, ethnicity, and menopausal status in all women.

  • Adjusted for age, ethnicity, menopausal status, and height.

  • Adjusted for age, ethnicity, menopausal status, and BMI.