Table 2.

Association between genotypes and mammographic measures

MeasurementGH1 −57G>T Genotype, mean (SE)
F (P)GH1 −57G>T Genotype, mean (SE)
F (P)
GGGTTTGG/GTTT
All womenn = 138n = 153n = 57n = 291n = 57
    % Density29.90 (1.79)26.29 (1.62)33.13 (2.38)3.25 (0.04)27.84 (1.36)33.02 (2.39)4.82 (0.03)
    Dense area (cm2)32.67 (2.32)29.48 (2.09)33.80 (3.08)1.33 (0.26)30.85 (1.76)33.70 (3.08)1.68 (0.20)
    Nondense area (cm2)108.58 (4.88)113.40 (4.40)94.95 (6.49)4.16 (0.02)111.34 (3.70)95.10 (6.49)6.25 (0.01)
Premenopausal womenn = 75n = 77n = 25n = 152n = 25
    % Density31.41 (2.57)27.38 (2.37)35.98 (3.80)2.11 (0.12)29.16 (2.00)35.71 (3.81)3.19 (0.08)
    Dense area (cm2)33.76 (3.38)29.58 (3.12)35.21 (5.01)0.89 (0.41)31.43 (2.63)34.94 (5.00)1.05 (0.31)
    Nondense area (cm2)95.52 (6.06)103.44 (5.60)84.69 (8.98)2.22 (0.11)99.93 (4.71)85.22 (8.97)2.82 (0.10)
Postmenopausal womenn = 63n = 76n = 32n = 139n = 32
    % Density27.74 (2.53)25.31 (2.22)30.16 (3.03)1.07 (0.34)26.31 (1.86)30.15 (3.03)1.71 (0.19)
    Dense area (cm2)30.44 (3.18)29.75 (2.78)32.11 (3.80)0.36 (0.70)30.03 (2.33)32.11 (3.79)0.62 (0.43)
    Nondense area (cm2)120.62 (7.82)124.85 (6.84)105.40 (9.35)1.94 (0.15)123.11 (5.74)105.42 (9.33)3.38 (0.07)
  • NOTE: The least-squares means presented here are adjusted for age, ethnicity, and BMI. For all women, the means are also adjusted for menopausal status. The analyses were conducted using the transformed outcome variable, and the means presented are the least-squares-adjusted untransformed means.