Table 4.

Combined effects of haplotypes derived from the observed genotypes of XRCC1 194, 280, and 399 on risk of CBP

Haplotypes*Cases
Controls
χ2POR (95% CI)χ2 for ORP
n (%)n (%)
HAP1 (111)81 (26.9)83 (27.8)0.020.881.00
HAP2 (112)78 (25.9)82 (27.4)0.100.750.97 (0.63-1.51)0.010.91
HAP3 (121)52 (17.3)18 (6.0)16.510.000052.96 (1.60-5.49)12.390.001
HAP4 (211)54 (17.9)80 (26.8)5.040.020.69 (0.44-1.10)2.460.12
HAP5 (212)6 (2.0)10 (3.3)1.000.310.61 (0.21-1.70)0.830.37
HAP6 (221)25 (8.3)26 (8.7)0.020.890.99 (0.53-1.85)0.0020.96
HAP7 (222)5 (1.7)0 (0.0)5.000.03
  • * The allele order is XRCC1 Arg194Trp, Arg280His, and Arg399Gln from left to right. Wild-type allele is indicated by 1 and variant alleles by 2.

  • Some data were missing due to inability to amplify DNA.

  • Person χ2 test for difference in distributions between the case and control groups.