Table 3.

Correlation between Grantham and SIFT, Grantham and PolyPhen, and PolyPhen and SIFT predictions

Grantham prediction
ConservativeModerately conservativeModerately radicalRadicalTotal
SIFT prediction
    Tolerant471 (29.0)418 (25.7)79 (4.9)19 (1.2)987 (60.7)
    Borderline94 (5.8)66 (4.1)29 (1.8)9 (0.6)198 (12.2)
    Potentially intolerant46 (2.8)53 (3.3)13 (0.8)5 (0.3)117 (7.2)
    Intolerant100 (6.2)128 (7.9)57 (3.5)39 (2.4)324 (20.0)
    Total711 (43.7)665 (40.9)178 (10.9)72 (4.4)1626 (100)
ρ = −0.188; 95% CI: −0.234, −0.141
Grantham prediction

Conservative
Moderately conservative
Moderately radical
Radical
Total
PolyPhen prediction
    Benign381 (25.0)266 (17.5)43 (2.8)16 (1.1)706 (46.4)
    Borderline79 (5.2)82 (5.4)14 (0.9)2 (0.1)177 (11.6)
    Potentially damaging97 (6.4)96 (6.3)18 (1.2)4 (0.3)215 (14.1)
    Possibly damaging84 (5.5)115 (7.6)52 (3.4)12 (0.8)263 (17.3)
    Probably damaging25 (1.6)68 (4.5)34 (2.2)35 (2.3)162 (10.6)
    Total666 (43.7)627 (41.2)161 (10.6)69 (4.5)1,523 (100)
ρ = 0.281; 95% CI, 0.234, 0.326
SIFT prediction

Tolerant
Borderline
Potentially intolerant
Intolerant
Total
PolyPhen prediction
    Benign359 (34.2)57 (5.4)25 (2.4)37 (3.5)478 (45.5)
    Borderline76 (7.2)20 (1.9)8 (0.8)15 (1.4)119 (11.3)
    Potentially damaging92 (8.8)21 (2.0)12 (1.1)32 (3.0)157 (15.0)
    Possibly damaging68 (6.5)27 (2.6)17 (1.6)72 (6.9)184 (17.5)
    Probably damaging32 (3.0)10 (1.0)10 (1.0)60 (5.7)112 (10.7)
    Total627 (59.7)135 (12.9)72 (6.9)216 (20.6)1050 (100)
ρ = −0.442; 95% CI, −0.490, −0.392
  • NOTE: Percentages are shown in parentheses.

    Abbreviation: 95% CI, 95% confidence interval.