Table 5.

False-positive report probability

PolymorphismOverall
Prior probability
Current smokers
Prior probability
Never smokers
Prior probability
OR (95% CI)PPower0.50.250.10.010.001OR (95% CI)PPower0.50.250.10.010.001OR (95% CI)PPower0.50.250.10.010.001
XPD-35931
    A/C vs A/A1.10 (0.72-1.60)0.6120.950.390.660.850.981.001.13 (0.64-2.00)0.6720.840.450.710.880.991.000.61 (0.24-1.57)0.3050.430.420.680.870.991.00
    C/C vs A/A1.28 (0.74-2.20)0.3800.710.350.610.830.981.002.23 (0.96-5.20)0.0620.180.260.510.760.971.000.79 (0.20-3.08)0.7340.600.550.790.920.991.00
    (C/C+A/C) vs A/A1.11 (0.76-1.60)0.5940.940.390.660.850.981.001.31 (0.76-2.20)0.3240.690.320.580.810.981.000.64 (0.26-1.58)0.3330.460.420.680.870.991.00
PCNA-6084
    C/G vs G/G1.57 (0.95-2.60)0.0800.430.160.360.630.950.991.46 (0.70-3.10)0.3160.530.370.640.840.981.001.40 (0.42-4.67)0.5840.540.520.760.910.991.00
    C/C vs G/G1.99 (0.43-9.20)0.3790.360.510.760.900.991.002.97 (0.33-26.50)0.3300.270.550.790.920.991.000.003 (0.00-∼)0.8230.420.660.860.950.991.00
    (C/C+C/G) vs G/G1.61 (1.00-2.60)0.0530.390.120.290.550.930.991.58 (0.78-3.20)0.2020.440.310.580.800.981.001.21 (0.37-3.98)0.7540.640.540.780.910.991.00
XRCC1-28152
    A/G vs G/G0.78 (0.54-1.20)0.2100.790.210.440.710.961.000.79 (0.45-1.40)0.4080.720.360.630.840.981.000.82 (0.32-2.13)0.6840.660.510.760.900.991.00
    A/A vs G/G0.71 (0.40-1.30)0.2350.590.290.550.780.981.000.49 (0.20-1.20)0.1080.240.310.570.800.981.001.29 (0.36-4.59)0.6940.590.540.780.910.991.00
    (A/A+A/G) vs G/G0.77 (0.53-1.10)0.1510.790.160.370.630.950.990.72 (0.43-1.20)0.2220.610.270.520.770.971.000.93 (0.39-2.23)0.8710.770.530.770.910.991.00
XRCC3-18067
    C/T vs C/C1.38 (0.93-2.10)0.1110.660.140.330.600.940.991.96 (1.09-3.50)0.0240.190.120.280.540.930.992.02 (0.72-5.66)0.1810.290.390.660.850.981.00
    T/T vs C/C1.45 (0.87-2.40)0.1550.550.220.460.720.971.002.65 (1.21-5.80)0.0150.080.160.360.6 30.950.994.34 (1.14-16.46)0.0310.060.340.610.820.981.00
    (T/T+C/T) vs C/C1.40 (0.97-2.03)0.0760.640.110.260.520.920.992.12 (1.21-3.70)0.0080.110.070.180.400.880.992.42 (0.91-6.46)0.0780.170.310.580.800.981.00
  • NOTE: Prior probabilities ranging from 0.5 to 0.001, with the estimated statistical power to detect an OR of 1.5 or 0.67 (if observed ORs were >1 or <1, respectively) with α level equal to the observed P value. Bold type indicates the false-positive report probability for the most likely prior probabilities.