Table 3.

ORs and 95% CIs for the joint effects of XRCC1-26651A>G versus XRCC3-18067C>T, XRCC1-26651A>G versus XRCC3-17893A>G, and ERCC1-19007T>C versus XRCC3-18067C>T polymorphisms

XRCC1-26651XRCC3-18067
C/C
C/T
T/T
Controls, n (%)Cases, n (%)OR (95% CI)Controls, n (%)Cases, n (%)OR (95% CI)Controls, n (%)Cases, n (%)OR (95% CI)
    A/A38 (36.5)26 (29.9)1.0055 (40.7)46 (33.1)1.0023 (45.1)15 (25.0)1.00
    A/G47 (45.2)49 (56.3)1.57 (0.78-3.16)55 (40.7)61 (43.9)1.91 (1.01-3.63)23 (45.1)29 (48.3)2.66 (0.93-7.70)
    G/G19 (18.3)12 (13.8)1.17 (0.45-3.06)25 (18.5)32 (23.0)1.18 (0.56-2.52)5 (9.8)16 (26.7)9.77 (2.18-43.71)
104871351395160
P = 0.07, test for interaction.

XRCC3-17893
XRCC1-26651A/A
A/G
G/G

Controls, n (%)
Cases, n (%)
OR (95% CI)
Controls, n (%)
Cases, n (%)
OR (95% CI)
Controls, n (%)
Cases, n (%)
OR (95% CI)
    A/A68 (44.4)50 (31.3)1.0040 (33.3)32 (29.6)1.008 (47.1)5 (27.8)1.00
    A/G65 (42.5)72 (45.0)1.85 (1.05-3.27)55 (45.8)56 (51.9)1.40 (0.71-2.80)5 (29.4)11 (61.1)3.52 (0.75-16.38)
    G/G20 (13.1)38 (23.8)2.92 (1.36-6.24)25 (20.8)20 (18.5)0.98 (0.42-2.27)4 (23.5)2 (11.1)0.80 (0.10-6.10)
1531601201081718
P = 0.11, test for interaction.

XRCC3-17893
ERCC1-19007A/A
A/G
G/G

Controls, n (%)
Cases, n (%)
OR (95% CI)
Controls, n (%)
Cases, n (%)
OR (95% CI)
Controls, n (%)
Cases, n (%)
OR (95% CI)
    T/T43 (33.6)54 (41.9)1.0039 (37.5)32 (40.5)1.003 (20.0)12 (70.6)1.00
    C/T67 (52.3)49 (38.0)0.48 (0.25-0.89)56 (53.8)39 (49.4)0.82 (0.40-1.71)9 (60.0)4 (23.5)0.11 (0.14-0.73)
    C/C18 (14.1)26 (20.2)1.38 (0.59-3.25)9 (8.7)8 (10.1)1.28 (0.37-4.45)3 (20.0)1 (5.9)0.08 (0.01-0.88)
128129104791517
P = 0.05, test for interaction.
  • NOTE: ORs were adjusted for age and smoking.