Table 2.

Case-control distribution of genotypes for the different DNA repair gene polymorphisms

Overall
Current smokers
Ex-smokers
Never smokers
Controls, n (%)Cases, n (%)OR (95% CI)Controls, n (%)Cases, n (%)OR (95%CI)Controls, n (%)Cases, n (%)OR (95% CI)Controls, n (%)Cases, n (%)OR (95% CI)
XPD-23591
    G/G103 (33.8)92 (31.5)1.0034 (32.1)52 (31.0)1.0033 (31.7)30 (30.9)1.0036 (37.9)10 (37.0)1.00
    A/G155 (50.8)153 (52.4)1.05 (0.70-1.57)58 (54.7)92 (54.8)1.06 (0.59-1.91)50 (48.1)47 (48.5)1.02 (0.51-2.02)47 (49.5)14 (51.9)1.08 (0.41-2.85)
    A/A47 (15.4)47 (16.1)1.14 (0.65-1.98)14 (13.2)24 (14.3)1.36 (0.56-3.31)21 (20.2)20 (20.6)1.02 (0.44-2.34)12 (12.6)3 (11.1)0.96 (0.21-4.33)
XPD-35931
    A/A100 (31.8)97 (30.7)1.0040 (36.0)57 (31.3)1.0031 (29.5)28 (26.9)1.0029 (29.6)12 (40.0)1.00
    A/C166 (52.9)167 (52.8)1.10 (0.72-1.59)57 (51.4)92 (50.5)1.13 (0.64-1.99)55 (52.4)61 (58.7)1.28 (0.65-2.52)54 (55.1)14 (46.7)0.61 (0.24-1.57)
    C/C48 (15.3)52 (16.5)1.28 (0.74-2.22)14 (12.6)33 (18.1)2.23 (0.96-5.18)19 (18.1)15 (14.4)0.88 (0.36-2.17)15 (15.3)4 (13.3)0.79 (0.20-3.08)
PCNA-6084
    G/G248 (84.6)225 (79.2)1.0092 (86.0)132 (79.5)1.0088 (88.0)74 (78.7)1.0068 (79.1)19 (79.2)1.00
    C/G42 (14.3)53 (18.7)1.57 (0.95-2.60)14 (13.1)29 (17.5)1.46 (0.70-3.06)12 (12.0)19 (20.2)1.87 (0.81-4.34)16 (18.6)5 (20.8)1.40 (0.42-4.67)
    C/C3 (1.0)6 (2.1)1.99 (0.43-9.21)1 (0.9)5 (3.0)2.97 (0.33-26.49)0 (0.0)1 (1.1)156.14 (0-4.84e13)2 (2.3)0 (0.0)0.003 (0-3.41e19)
XRCC1-26304
    C/C260 (83.1)275 (87.3)1.0090 (81.8)157 (86.3)1.0088 (84.6)90 (87.4)1.0082 (82.8)28 (93.3)1.00
    C/T51 (16.3)40 (12.7)0.69 (0.47-1.14)19 (17.3)25 (13.7)0.69 (0.35-1.39)16 (15.4)13 (12.6)0.83 (0.35-1.93)16 (16.2)2 (6.7)0.39 (0.08-1.91)
    T/T2 (0.6)0 (0.0)0.03 (0-8.86e5)1 (0.9)0 (0.0)0.01 (0-4.04e9)0 (0.0)0 (0.0)1 (1.0)0 (0.0)0.04 (0-3.67e17)
XRCC1-26651
    A/A116 (40.0)87 (30.4)1.0047 (43.5)53 (31.5)1.0041 (39.8)27 (27.8)1.0028 (35.4)7 (33.3)1.00
    A/G125 (43.1)139 (48.6)1.77 (1.17-2.70)41 (38.0)81 (48.2)1.96 (1.08-3.56)48 (46.6)48 (49.5)1.84 (0.94-3.62)36 (45.6)10 (47.6)1.00 (0.31-3.22)
    G/G49 (16.9)60 (21.0)1.63 (0.96-2.75)20 (18.5)34 (20.2)1.61 (0.77-3.37)14 (13.6)22 (22.7)1.97 (0.82-4.73)15 (19.0)4 (19.0)0.97 (0.22-4.25)
P = 0.05
XRCC1-28152
    G/G120 (38.5)136 (43.7)1.0046 (41.8)81 (45.3)1.0035 (33.7)42 (41.2)1.0039 (39.8)13 (43.3)1.00
    A/G145 (46.5)135 (43.4)0.78 (0.54-1.15)48 (43.6)79 (44.1)0.79 (0.45-1.38)54 (51.9)44 (43.1)0.75 (0.40-1.44)43 (43.9)12 (40.0)0.82 (0.32-2.13)
    A/A47 (15.1)40 (12.9)0.71 (0.40-1.25)16 (14.5)19 (10.6)0.49 (0.20-1.17)15 (14.4)16 (15.7)0.79 (0.32-1.91)16 (16.3)5 (16.7)1.29 (0.36-4.59)
XRCC3-4541
    T/T201 (63.8)207 (65.5)1.0070 (63.1)119 (65.0)1.0072 (69.2)64 (62.1)1.0059 (59.0)24 (80.0)1.00
    C/T102 (32.4)98 (31.0)0.92 (0.63-1.35)37 (33.3)56 (30.6)0.97 (0.55-1.68)28 (26.9)37 (35.9)1.48 (0.78-2.80)37 (37.0)5 (16.7)0.25 (0.08-0.76)
    C/C12 (3.8)11 (3.5)0.71 (0.27-1.85)4 (3.6)8 (4.4)0.93 (0.24-3.55)4 (3.8)2 (1.9)0.54 (0.09-3.26)4 (4.0)1 (3.3)0.46 (0.04-4.89)
XRCC3-17893
    A/A166 (53.4)171 (55.3)1.0057 (51.4)106 (59.6)1.0058 (55.2)51 (50.5)1.0051 (53.7)14 (46.7)1.00
    A/G126 (40.5)117 (37.9)0.96 (0.66-1.39)43 (38.7)63 (35.4)0.73 (0.42-1.27)43 (41.0)41 (40.6)1.20 (0.65-2.21)40 (42.1)13 (43.3)1.23 (0.50-3.06)
    G/G19 (6.1)21 (6.8)0.90 (0.44-1.84)11 (9.9)9 (5.1)0.30 (0.11-0.82)4 (3.8)9 (8.9)3.04 (0.82-11.25)4 (4.2)3 (10.0)2.12 (0.40-11.13)
XRCC3-18067
    C/C117 (36.9)99 (31.2)1.0042 (37.8)48 (26.2)1.0036 (34.3)44 (42.3)1.0039 (38.6)7 (23.3)1.00
    C/T148 (46.7)155 (48.9)1.38 (0.93-2.05)54 (48.6)94 (51.4)1.96 (1.09-3.52)44 (41.9)45 (43.3)0.82 (0.43-1.56)50 (49.5)16 (53.3)2.02 (0.72-5.66)
    T/T52 (16.4)63 (19.9)1.45 (0.87-2.42)15 (13.5)41 (22.4)2.65 (1.21-5.80)25 (23.8)15 (14.4)0.48 (0.21-1.11)12 (11.9)7 (23.3)4.34 (1.14-16.46)
P = 0.05
ERCC1-19007
    T/T86 (34.5)99 (43.2)1.0029 (30.5)56 (42.4)1.0028 (35.4)32 (40.5)1.0029 (38.7)11 (61.1)1.00
    C/T132 (53.0)94 (41.0)0.53 (0.34-0.84)56 (58.9)54 (40.9)0.55 (0.29-1.02)39 (49.4)35 (44.3)0.59 (0.28-1.27)37 (49.3)5 (27.8)0.33 (0.09-1.17)
    C/C31 (12.4)36 (15.7)1.06 (0.55-2.02)10 (10.5)22 (16.7)1.33 (0.51-3.43)12 (15.2)12 (15.2)0.94 (0.34-2.66)9 (12.0)2 (11.1)0.75 (0.11-5.13)
P = 0.033P = 0.026
ERCC4-30028
    T/T106 (49.8)92 (45.1)1.0041 (52.6)53 (43.1)1.0032 (47.1)35 (50.0)1.0033 (49.3)4 (36.4)1.00
    C/T79 (37.1)87 (42.6)1.45 (0.90-2.35)25 (32.1)50 (40.7)1.56 (0.79-3.07)27 (39.7)31 (44.3)1.16 (0.54-2.49)27 (40.3)6 (54.5)2.56 (0.57-11.47)
    C/C28 (13.1)25 (12.3)1.06 (0.52-2.16)12 (15.4)20 (16.3)1.57 (0.63-3.92)9 (13.2)4 (5.7)0.41 (0.11-1.63)7 (10.4)1 (9.1)1.69 (0.14-19.9)
ERCC4-30147
    A/A272 (93.5)274 (94.8)1.00103 (96.3)158 (92.9)1.0090 (91.8)93 (97.9)1.0079 (91.9)23 (95.8)1.00
    A/G19 (6.5)15 (5.2)0.75 (0.33-1.71)4 (3.7)12 (7.1)1.61 (0.46-5.57)8 (8.2)2 (2.1)0.24 (0.05-1.24)7 (8.1)1 (4.2)0.74 (0.07-7.37)
XRCC2-31479
    G/G94 (86.2)133 (85.3)1.0033 (86.8)83 (91.2)1.0039 (86.7)38 (74.5)1.0022 (84.6)12 (85.7)1.00
    A/G13 (11.9)22 (14.1)1.78 (0.77-4.12)4 (10.5)8 (8.8)1.27 (0.31-5.16)5 (11.1)12 (23.5)2.81 (0.82-9.65)4 (15.4)2 (14.3)1.97 (0.20-18.9)
    A/A2 (1.8)1 (0.6)0.54 (0.04-6.50)1 (2.6)0 (0.0)0.002 (0-1.97e16)1 (2.2)1 (2.0)1.16 (0.07-20.02)0 (0.0)0 (0.0)
  • NOTE: OR and 95% CI values are reported; ORs were adjusted for age and smoking in the overall population and for age in the stratified analysis. χ2 P values from 3 × 2 contingency tables are shown when significant.