Predictors | Estimate | SE* | 95% CI^{†} | P | ||||
---|---|---|---|---|---|---|---|---|

Model 1: Fixed effects | ||||||||

Intercept | −0.155 | 0.047 | −0.183 to −0.089 | <0.0001 | ||||

Age^{‡} | −0.005 | 0.005 | −0.02 to 0.01 | 0.38 | ||||

GSTT1(−) | 0.076 | 0.036 | −0.001 to 0.154 | 0.03 | ||||

Age^{‡} × log_{10} drinking water As (μg/L) | 0.010 | 0.004 | 0.0001 to 0.02 | 0.02 | ||||

Log_{10} drinking water As (μg/L)^{§} | 0.191 | 0.012 | — | <0.0001 | ||||

Model 2: Gene-environment interaction | ||||||||

Intercept | −0.135 | 0.051 | −0.169 to 0.058 | <0.001 | ||||

Age^{‡} | −0.010 | 0.005 | −0.025 to 0.005 | 0.28 | ||||

GSTT1(−) | −0.064 | 0.053 | −0.181 to 0.036 | 0.41 | ||||

Age^{‡} × log_{10} drinking water As (μg/L) | 0.010 | 0.005 | 0.002 to 0.02 | 0.02 | ||||

GSTT1(−) × log_{10} drinking water As (μg/L) | 0.125 | 0.035 | 0.064-0.2 | 0.001 | ||||

Log_{10} drinking water As (μg/L)^{§} | 0.177 | 0.013 | — | <0.0001 |

NOTE: The estimates for drinking water concentrations are valid above 2 μg As/L.

↵* SEs estimated via bootstrap (500 resampled statistics).

↵† Nonparametric bootstrap bias-corrected accelerated 95% CIs.

↵‡ Intercept is for median age of 27 years and the estimate is for 5-year increments.

↵§ Estimates of drinking water effect are based on fully parametric model approximating the nonparametric effect depicted in Figs. 2 and 4 for drinking water above 2 μg As/L.