Table 4.

Association among combined TS genotype, postmenopausal hormone (PMH) use, and colon cancer in postmenopausal women

TS 3′-UTR 1494delTTAAAG genotype
ins/ins
ins/del and del/del
TSER genotypeCases (n)Controls (n)OR (995% CI)Cases (n)Controls (n)OR (95% CI)
No, PMH
    3rpt/3rpt41421.0 (reference)801130.7 (0.4-1.2)
    3/2 or 2/2rpt1782080.9 (0.5-1.4)1641820.9 (0.5-1.4)
Yes, PMH
    3rpt/3rpt2192.2 (0.9-5.4)21560.4 (0.2-0.7)
    3/2 or 2/2rpt48890.5 (0.3 to <1.0)53870.6 (0.3 to > 1.0)
  • NOTE: Adjusted for age, body mass index, lifetime vigorous activity, energy intake, dietary fiber, dietary calcium, and usual number of cigarettes smoked. P < 0.01 (Wald χ2 test of slopes) for TSER 3rpt/3rpt genotype across 3′-UTR genotypes. P = 0.03 (Wald χ2 test of slopes) for 3′-UTR insertion/insertion genotype across TSER genotypes.