Table 3.

Association between polymorphisms in the folate pathway and colon cancer

Men
Women
GenotypeCases (n)Controls (n)OR (95% CI)Cases (n)Controls (n)OR (95% CI)
TSERMTHFR 677C>T
    3rpt/3rptCC or CT2662421.0 (reference)1722261.0 (reference)
TT28410.6 (0.4-1.0)18280.9 (0.5-1.7)
    3/2rpt or 2/2rptCC or CT5446680.7 (0.6-0.9)4565921.0 (0.8-1.3)
TT50810.6 (0.4-0.9)52750.9 (0.6-1.4)
MTHFR 1298A>C
    3rpt/3rptAA or AC2612541.0 (reference)1752191.0 (reference)
CC34291.2 (0.7-2.0)15350.5 (0.3 to <1.0)
    3/2 or 2/2rptAA or AC5356760.8 (0.6 to <1.0)4635891.0 (0.8-1.2)
CC59740.8 (0.5-1.1)45780.7 (0.5-1.1)
TS 3′-UTRMTHFR 677C>T
    ins/insCC or CT3474181.0 (reference)2973591.0 (reference)
TT40491.0 (0.6-1.6)31500.8 (0.5-1.2)
    Any deletionCC or CT4634921.1 (0.9-1.3)3314590.9 (0.7-1.1)
TT38730.6 (0.4-0.9)39530.9 (0.6-1.4)
MTHFR 1298A>C
    ins/insAA or AC3464201.0 (reference)2983541.0 (reference)
CC41481.0 (0.6-1.5)30550.6 (0.4-1.0)
    Any deletionAA or AC4505101.0 (0.8-1.2)3404540.9 (0.7-1.1)
CC52551.1 (0.7-1.7)30580.6 (0.4 to <1.0)
MTR D919GMTHFR 677C>T
    DDCC or CT5075831.0 (reference)4025331.0 (reference)
TT47830.7 (0.5 to <1.0)56671.1 (0.8-1.6)
    DG or GGCC or CT3073331.0 (0.9-1.3)2302891.1 (0.9-1.3)
TT31400.9 (0.6-1.5)15360.6 (0.3-1.1)
MTHFR 1298A>C
    DDAA or AC4955971.0 (reference)4175231.0 (reference)
CC60701.0 (0.7-1.5)41770.7 (0.4 to <1.0)
    DG or GGAA or AC3043401.1 (0.9-1.3)2262891.0 (0.8-1.2)
CC34331.2 (0.7-2.0)19360.7 (0.4-1.2)
RFC 80G>AMTHFR 677C>T
    GGCC or CT2742791.0 (reference)1942361.0 (reference)
TT27380.7 (0.4-1.1)16310.7 (0.3-1.2)
    GA or AACC or CT5406360.8 (0.7-1.0)4385860.9 (0.7-1.1)
TT51850.6 (0.4-0.9)55720.9 (0.6-1.4)
MTHFR 1298A>C
    GGAA or AC2672831.0 (reference)1942361.0 (reference)
CC34341.1 (0.7-1.9)16310.6 (0.3-1.1)
    GA or AAAA or AC5326530.8 (0.7 to >1.0)4495760.9 (0.7-1.2)
CC60690.9 (0.6-1.3)44820.6 (0.4 to <1.0)
  • NOTE: Adjusted for age, BMI, lifetime vigorous leisure activity, energy intake, dietary fiber, dietary calcium, usual number of cigarettes smoked, and other TS polymorphisms where appropriate (TSER, TS3′UTR). Pinteraction values of gene-gene associations were not statistically significant on an additive or multiplicative scale (data not shown).