Table 3.

Associations between polymorphisms in MGMT, XPD, and XPG and risk of colorectal polyps

GeneGenotypesControls, nAdenomatous polyps only
Hyperplastic polyps only
Adenomatous and hyperplastic polyps
nOR* (95% CI)nOR* (95% CI)nOR* (95% CI)
MGMTL-I/L-I (wt/wt)3582501.00 (Reference)1141.00 (Reference)711.00 (Reference)
L-I/F-I101540.71 (0.47-1.07)411.35 (0.85-2.15)210.96 (0.51-1.80)
L-I/L-V102630.90 (0.60-1.33)321.00 (0.61-1.63)140.81 (0.41-1.60)
F-I/F-I1020.27 (0.05-1.38)20.81 (0.16-4.06)32.20 (0.49-9.86)
F-I/L-V or L-I/F-V33210.90 (0.48-1.68)30.31 (0.09-1.07)111.88 (0.80-4.39)
F-I/F-V3000
L-V/L-V630.83 (0.19-3.67)21.05 (0.19-5.89)22.69 (0.45-16.21)
L-V/F-V210.45 (0.03-5.92)00
F-V/F-V0100
Homozygous wt3582501.00 (Reference)1141.00 (Reference)711.00 (Reference)
Heterozygous2031170.80 (0.59-1.09)731.17 (0.81-1.70)350.89 (0.54-1.47)
Homozygous variant54280.74 (0.44-1.26)70.45 (0.19-1.05)161.79 (0.88-3.64)
XPDD-K/D-K (wt/wt)1871091.00 (Reference)581.00 (Reference)441.00 (Reference)
D-K/N-K39231.01 (0.57-1.78)100.83 (0.39-1.76)101.09 (0.51-2.35)
D K/D-Q52381.25 (0.78-2.03)211.30 (0.72-2.34)90.74 (0.34-1.60)
D-K/N-Q or N-K/D-Q2301401.04 (0.76-1.43)670.94 (0.63-1.40)400.74 (0.46-1.18)
N-K/N-K123.43 (0.31-38.28)13.22 (0.20-52.36)0
N-K/N-Q26130.86 (0.42-1.74)70.87 (0.36-2.10)30.49 (0.14-1.69)
D-Q/D-Q146.86 (0.76-62.18)13.22 (0.20-52.36)14.25 (0.26-69.28)
D-Q/N-Q28231.41 (0.77-2.57)91.04 (0.46-2.32)40.61 (0.20-1.82)
N-Q/N-Q50431.48 (0.92-2.36)211.35 (0.75-2.44)100.85 (0.40-1.81)
Homozygous wt1871091.00 (Reference)581.00 (Reference)441.00 (Reference)
Heterozygous3212011.10 (0.80-1.53)980.94 (0.62-1.40)590.92 (0.56-1.50)
Homozygous variant106851.57 (1.04-2.38)391.29 (0.77-2.15)181.01 (0.51-2.01)
XPGD1104/D11043532471.00 (Reference)1221.00 (Reference)711.00 (Reference)
D1104/H11042261250.86 (0.64-1.16)680.93 (0.64-1.34)441.12 (0.70-1.79)
H1104/H110437230.94 (0.52-1.72)60.36 (0.13-0.98)71.11 (0.44-2.82)
  • * Multivariate adjusted for age, sex, BMI, kcal, alcohol intake, dietary fiber, regular NSAIDs use, hormone replacement therapy, and pack-years of smoking.

  • Heterozygotes: L-I/F-I and L-I/L-V; homozygous variants: F-I/F-I, F-I/L-V or L-I/F-V, F-I/FV, L-V/L-V, L-V/F-V, and F-V/F-V.

  • Heterozygotes: D-K/N-K, D-K/D-Q, D-K/N-Q, or N-K/D-Q; homozygous variant: N-K/N-K, N-K/N-Q, D-Q/D-Q, D-Q/N-Q, and N-Q/N-Q.