Table 3.

Association between incident cancer events and inflammatory markers

Inflammatory markersHR* (95% CI) Number of events
All cancer events
Nonfatal cancer events
Cancer death
UnadjustedAdjustedNSAIDs users excludedAdjustedAdjustedNSAIDs users excluded
log(IL-6), pg/mL1.18 (0.98-1.41) 2731.13 (0.94-1.37) 2731.10 (0.90-1.35) 2290.95 (0.75-1.19) 1891.63 (1.19-2.23) 841.65 (1.19-2.29) 80
log(CRP), mg/L1.17 (1.02-1.33) 2911.25 (1.09-1.43) 2911.23 (1.06-1.43) 2431.17 (1.00-1.38) 2011.41 (1.13-1.77) 901.51 (1.19-1.92) 85
log(TNF-α), pg/mL1.32 (1.00-1.76) 2751.28 (0.96-1.70) 2751.39 (1.02-1.90) 2291.07 (0.76-1.52) 1881.82 (1.14-2.92) 871.95 (1.20-3.15) 82
  • * Log-transformed variables: the HR present the associations with the inflammatory markers related to a unit change on the log scale.

  • HR adjusted for age, gender, race, and site.