Table 3.

Association between IL-8 −251 polymorphism and clinicopathologic features of gastric cancer

Variables (n)IL-8 −251 genotype
A/A vs. T/T
A carrier vs. T/T
A/AA/TA carrierT/TOR (95% CI)POR (95% CI)P
Healthy controls (252)22105127125
Overall gastric cancer (396)441912351612.22 (1.08-4.56)0.031.50 (1.00-2.25)0.05
Tumor location
    Cardia (27)41216112.71 (0.69-10.58)0.151.28 (0.53-3.08)0.58
    Non-cardia (369)401792191501.99 (0.94-4.22)0.071.44 (0.95-2.19)0.09
    Upper third (82)153651313.66 (1.46-9.17)0.0061.56 (0.89-2.83)0.12
    Middle third (116)85967491.26 (0.47-3.38)0.651.37 (0.82-2.28)0.23
    Lower third (198)2196117811.95 (0.84-4.50)0.121.41 (0.88-2.26)0.15
Staging
    Early (250)291181471032.06 (0.95-4.47)0.071.41 (0.91-2.19)0.12
    Advanced (146)157388581.90 (0.77-4.69)0.161.47 (0.89-2.45)0.14
Lauren's classification
    Intestinal type (221)22100122991.59 (0.69-3.63)0.271.13 (0.71-1.79)0.60
    Diffuse type (175)2291113622.79 (1.21-6.39)0.021.88 (1.16-3.04)0.01
Japanese classification
    tub1 (113)105565481.49 (0.57-3.93)0.421.23 (0.73-2.01)0.44
    tub2 (108)124557511.68 (0.66-4.28)0.271.04 (0.61-1.77)0.89
    por (145)187593522.70 (1.14-6.38)0.021.84 (1.11-3.05)0.02
    sig (23)3131673.75 (0.81-17.37)0.092.35 (0.89-6.22)0.08
    muc (7)13432.54 (0.24-26.83)0.441.38 (0.30-6.44)0.68
Lymphatic and venous invasion
    Positive (151)187694572.23 (0.94-5.30)0.071.50 (0.91-2.48)0.11
    Negative (195)2196117781.95 (0.86-4.41)0.111.42 (0.89-2.25)0.14
Lymph node metastasis
    Positive (108)145367412.50 (1.01-6.20)0.051.59 (0.93-2.72)0.09
    Negative (286)301381681181.87 (0.86-4.06)0.121.39 (0.90-2.14)0.14
Peritoneal dissemination
    Positive (22)1131480.98 (0.11-8.80)0.991.71 (0.66-4.43)0.27
    Negative (372)431782211512.07 (0.98-4.38)0.061.42 (0.93-2.16)0.10
Liver metastasis
    Positive (12)35845.63 (1.06-30.04)0.041.83 (0.51-6.54)0.35
    Negative (382)411862271551.96 (0.92-4.16)0.081.43 (0.94-2.17)0.10
Other distant metastasis
    Positive (16)291153.00 (0.50-17.94)0.232.07 (0.67-6.40)0.21
    Negative (378)421822241542.00 (0.94-4.22)0.071.42 (0.93-2.16)0.10
p53 mutations
    Positive (143)196988552.95 (1.18-7.39)0.021.91 (1.13-3.26)0.02
    Negative (83)84250332.06 (0.72-5.85)0.181.73 (0.97-3.01)0.07
  • NOTE: A carrier, A/A + A/T. All data are adjusted for sex, age, and H. pylori seropositivity.