Table 2.

Association between cytokine gene genotypes and risk of atrophic gastritis and gastric cancer

GenotypeHealthy controls, n (%)Atrophic gastritis
Gastric cancer
n (%)OR (95% CI)Pn (%)OR (95% CI)P
IL-8 −251
    A/A22 (8.7)26 (12.1)2.35 (1.12-4.94)0.0244 (11.1)2.22 (1.08-4.56)0.03
    A/T105 (41.7)99 (46.0)1.35 (0.87-2.11)0.18191 (48.2)1.38 (0.91-2.11)0.13
    A carrier127 (50.4)125 (58.1)1.50 (0.98-2.23)0.06235 (59.3)1.50 (1.00-2.25)0.05
    T/T125 (49.6)90 (41.9)1.0 (Reference)161 (40.7)1.0 (Reference)
IL-1B −511*
    T/T49 (19.6)46 (21.4)1.40 (0.76-2.61)0.2881 (21.7)1.69 (0.92-3.08)0.09
    T/C133 (53.2)104 (48.4)0.93 (0.57-1.52)0.77188 (50.4)1.08 (0.67-1.73)0.77
    T carrier182 (72.8)150 (69.8)1.04 (0.65-1.66)0.86269 (72.1)1.22 (0.77-1.92)0.40
    C/C68 (27.2)65 (30.2)1.0 (Reference)104 (27.9)1.0 (Reference)
IL-1RN
    *2/*22 (0.8)0 (0)01.003 (0.8)1.09 (0.09-13.70)0.95
    *2/L21 (8.8)17 (8.2)1.08 (0.49-2.41)0.8425 (6.8)0.71 (0.32-1.57)0.39
    *2 carrier23 (9.7)17 (8.2)0.83 (0.43-1.60)0.5828 (7.7)0.78 (0.44-1.38)0.39
    L/L215 (90.3)191 (91.8)1.0 (Reference)337 (92.3)1.0 (Reference)
  • NOTE: A carrier, A/A + A/T; T carrier, T/T + T/C; L, alleles 1, 3, 4, and 5. *2 carrier, *2/*2 + *2/L. ORs are adjusted for sex, age, and H. pylori seropositivity.

  • * Two healthy control and 23 gastric cancer samples could not be genotyped.

  • Fourteen healthy-control, 7 atrophic-gastritis, and 31gastric cancer samples could not be genotyped.