Table 3.

ORs for BE and BE with dysplasia associated with smoking, obesity, and NSAIDs

ExposureControls (%), n = 261BE
BE with dysplasia
n = 117 (%)Crude OR (95% CI)*Adjusted OR (95% CI)n = 50 (%)Crude OR (95% CI)*Adjusted OR (95% CI)
Cigarette smoking intensity (pack-years)
    None46271.01.0181.01.0
    ≤2528442.5 (1.5-4.4)3.1 (1.6-6.0)443.7 (1.6-8.5)3.8 (1.4-10.3)
    ≥2526292.1 (1.1-3.8)2.2 (1.1-4.5)382.9 (1.2-6.9)3.3 (1.2-9.5)
Maximum BMI (kg/m2)
    18.5-24.925221.01.0121.01.0
    25-29.946361.0 (0.5-1.7)0.9 (0.5-1.8)451.7 (0.6-4.4)1.3 (0.5-3.9)
    ≥3028421.7 (0.9-3.2)1.5 (0.7-3.1)432.9 (1.1-7.7)2.1 (0.7-6.4)
Aspirin/NSAIDS (frequency of use in past 5 y)
    Never23271.01.0241.01.0
    Occasionally32320.7 (0.4-1.4)0.8 (0.4-1.5)361.0 (0.4-2.2)0.9 (0.4-2.4)
    <2-3/mo12110.6 (0.3-1.3)0.8 (0.3-1.9)20.1 (0.0-1.1)0.1 (0.0-1.0)
    ≥1/wk34290.8 (0.4-1.5)0.6 (0.3-1.3)381.1 (0.5-2.6)0.8 (0.3-2.1)
Acetominophen (frequency of use in past 5 y)
    Never17131.01.061.01.0
    Occasionally51430.9 (0.4-1.7)0.7 (0.3-1.5)482.4 (0.7-8.3)2.6 (0.6-11.4)
    <2-3/mo19210.9 (0.4-2.1)1.0 (0.4-2.3)203.0 (0.7-11.9)4.1 (0.8-20.8)
    ≥1/wk14241.9 (0.8-4.1)1.3 (0.5-3.1)265.0 (1.3-19.3)3.1 (0.6-15.1)
  • Abbreviation: BE, Barrett's esophagus.

  • * ORs and 95% CIs adjusted for exact age (y) and sex.

  • ORs and 95% CIs adjusted for exact age (y), sex, frequency of acid reflux symptoms in current age group, BMI (continuous), pack-years smoked (continuous), and NSAID use.