Table 2.

ORs for BE and dysplastic BE associated with history of acid reflux

ExposureControls (%), n = 261BE
BE with dysplasia
n = 117 (%)Crude OR (95% CI)*Adjusted OR (95% CI)n = 50 (%)Crude OR (95% CI)*Adjusted OR (95% CI)
Acid reflux ever
    No50161.01.061.01.0
    Yes50844.9 (2.8-8.6)4.8 (2.7-8.5)9415.3 (4.6-50.5)16.9 (5.0-57.2)
Acid reflux past year
    Never62211.01.0171.01.0
    Monthly35363.0 (1.7-5.4)2.9 (1.6-5.4)353.6 (1.5-8.7)4.1 (1.6-10.5)
    Weekly34332.3 (13.4-78.1)29.7 (12.2-72.6)4851.5 (16.9-157)59.7 (18.5-193)
Acid reflux age 10-19 y
    Never94911.01.0861.01.0
    Monthly570.8 (0.3-2.3)0.8 (0.3-2.3)71.2 (0.3-4.6)1.2 (0.3-4.7)
    Weekly120.9 (0.1-7.0)1.7 (0.2-16.8)76.7 (1.2-38.4)13.2 (1.8-98.5)
Acid reflux age 20-29 y
    Never87691.01.0671.01.0
    Monthly11201.7 (0.9-3.4)1.7 (0.9-3.4)171.9 (0.8-4.7)2.1 (0.8-5.3)
    Weekly2115.0 (1.5-17.4)6.7 (1.7-26.6)1515.4 (3.8-70.0)24.5 (4.8-124)
Acid reflux age 30-49 y§
    Never75441.01.0311.01.0
    Monthly22321.8 (1.0-3.2)1.7 (0.9-3.0)403.5 (1.6-7.5)3.6 (1.6-8.1)
    Weekly3248.7 (3.6-21.4)9.9 (3.8-25.5)2921.2 (7.2-62.7)27.3 (8.5-87.4)
Acid reflux age 50-79 y
    Never56251.01.051.01.0
    Monthly40452.3 (1.2-4.6)2.2 (1.1-4.4)5514.3 (3.2-62.9)14.8 (3.3-66.5)
    Weekly53112.5 (4.9-31.9)13.5 (5.0-37.0)4089.7 (17.6-457)96.7 (18.2-514)
Acid reflux for current age group
    Never55211.01.091.01.0
    Monthly40432.7 (1.5-4.7)2.5 (1.4-4.6)497.2 (2.4-21.8)7.5 (2.5-22.9)
    Weekly53619.1 (8.5-43.2)19.9 (8.4-46.7)4259.1 (16.8-208)62.2 (16.8-230)
  • Abbreviation: BE, Barrett's esophagus.

  • * ORs and 95% CIs adjusted for exact age (y) and sex.

  • ORs and 95% CIs adjusted for exact age (y), sex, BMI (continuous), pack-years smoked (continuous), and NSAID use.

  • Analysis restricted to participants ages ≥25 y.

  • § Analysis restricted to participants ages ≥35 y.

  • Analysis restricted to participants ages ≥55 y.