Model | α_{aA}* | δ* | OR^{†}_{dysplastic nevi} (95% CI) | OR^{†}_{RHC variants} (CI) | OR^{†}_{high number of nevi} (CI) | Test statistic (χ^{2})^{‡} | P |
---|---|---|---|---|---|---|---|

1. Dysplastic nevi | −7.17 | 1.07 | 3.02 (1.51-6.05) | — | — | 9.06 | <0.01 |

2. RHC variants added to model 1 | −7.79 | 1.19 | 2.93 (1.46-5.88) | 2.21 (1.11-4.44) | — | 4.73 | 0.03 |

3. High number of nevi added to model 2 | −8.26 | 1.27 | 2.46 (1.19-5.05) | 2.19 (1.10-4.39) | 2.03 (0.99-4.12) | 3.74 | 0.053 |

↵*

*α*_{aA}is the genotype-specific baseline risk in carriers of*CDKN2A*mutations;*δ*is the regression coefficient specifying the variation of the hazard function with time.↵† The OR of hazard function associated with each covariate [OR = exp(

*β*)] and 95% CI were computed from the corresponding estimate of the regression parameter of that covariate (*β*).↵‡ Tests are based on likelihood ratios and are two sided (the number of degrees of freedom is 1). Likelihood ratio test comparing the absence of a given risk factor versus a model including that risk factor was done at each step of the stepwise procedure.