Table 4.

Effect of RHC variants in presence of host-related phenotypes using combined segregation-linkage analyses in CDKN2A mutation carriers

ModelOR*covariate (95% CI)Test statistic (χ2)P
RHC + hair color
    1. Effect of RHC2.08 (1.03-4.22)3.940.05
    2. Effect of red/blond hair1.96 (0.96-3.97)3.150.08
RHC + sunburns
    1. Effect of RHC2.33 (1.16-4.67)5.280.02
    2. Effect of high propensity to sunburn3.08 (0.91-10.46)4.170.04
RHC + dysplastic nevi
    1. Effect of RHC2.21 (1.11-4.44)4.730.03
    2. Effect of dysplastic nevi2.93 (1.46-5.88)8.53<0.01
RHC + number of nevi
    1. Effect of RHC2.26 (1.13-4.52)5.020.03
    2. Effect of high number of nevi2.47 (1.25-4.90)6.570.01
  • * The OR of hazard function associated with each covariate [OR = exp(β)] and 95% CI were computed from the corresponding estimate of the regression parameter of that covariate (β).

  • Tests are based on likelihood ratios and are two sided. Test of RHC variants was conducted by comparing a model with a given host factor (and no effect of RHC) to a model including both RHC and the host factor. Test of a given host factor was conducted by comparing a model with RHC variants (and no effect of the host factor) to a model including both RHC and the host factor. These likelihood ratio tests follow a χ2 with 1 degree of freedom.