Table 1.

Genotyped family members by melanoma affection status

CDKN2A and MC1R genotypesNo. individualsAffected subjects
Unaffected subjects
Unknown melanoma status*, no. subjects
No. casesMean age at onset ± SDNo. unaffectedMean age at exam ± SD
153 subjects genotyped for both CDKN2A and MC1R
CDKN2A, MC1R
    WT, consensus15140.001340.77 ± 15.051
    WT, one variant2102040.50 ± 22.071
    WT, two variants32128.003140.97 ± 19.210
    WT, three variants50546.60 ± 24.910
    Mut, consensus10552.60 ± 12.10548.80 ± 19.560
    Mut, one variant29848.13 ± 15.752034.10 ± 20.071
    Mut, two variants281746.71 ± 13.331135.09 ± 18.120
    Mut, three variants131250.08 ± 13.39123.00
13 subjects genotyped for either CDKN2A or MC1R
CDKN2A, MC1R
    WT, unknown50548.20 ± 15.350
    Mut, unknown2246.00 ± 11.3100
    Unk, consensus20229.00 ± 4.240
    Unk, two variants3144.00264.50 ± 16.260
    Unk, three variants10159.000
  • Abbreviations: WT, wild type for CDKN2A; Mut, mutation for CDKN2A; unk, unknown genotype for CDKN2A.

  • * Age at exam is unknown for individuals with unknown melanoma status.